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Mercury Toxicity and Neurodegenerative Effects

  • Alessia Carocci
  • Nicola Rovito
  • Maria Stefania SinicropiEmail author
  • Giuseppe GenchiEmail author
Chapter
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 229)

Abstract

Neurodegeneration is a broadly defined term that describes the loss of neuronal structure and function, and produces disorders known as neurodegenerative diseases. A common feature of neurodegeneration is the progressive cell loss in specific neuronal populations of the central nervous system (CNS), often associated with cytoskeletal protein changes that led to intracytoplasmic and/or intranuclear inclusions in neurons and/or glia. The neurological consequences of neurodegeneration in patients are often devastating and result in severe mental and physical effects, accounting for a large number of hospitalizations and disabilities. Although the causes of the majority of neurodegenerative diseases are still unknown, it has become increasingly clear that the major basic processes that induce neurodegeneration are multifactorial ones that are caused by genetic, endogenous, and environmental factors. Protein misfolding and aggregation, oxidative stress, mitochondrial dysfunction, and phosphorylation impairment are the major shared neurodegenerative pathogenic processes (Jellinger 2003).

Keywords

Amyotrophic Lateral Sclerosis Kawasaki Disease Amyotrophic Lateral Sclerosis Patient Lipoic Acid Inorganic Mercury 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

This work was supported by grants from Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR, Italy).

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© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Dipartimento di Farmacia-Scienze del FarmacoUniversità degli Studi di Bari “A. Moro”BariItalia
  2. 2.Dipartimento di Farmacia e Scienze della Salute e della NutrizioneUniversità della CalabriaArcavacata di Rende (Cosenza)Italia

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