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MicroRNAs in Solid Tumors

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MicroRNAs: Key Regulators of Oncogenesis

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Abstract

MicroRNAs (miRNAs) are a class of non-coding RNAs that hybridize to mRNAs inducing either translation repression or mRNA cleavage. MiRNAs regulate a variety of biological processes in the cell, including development, cell differentiation, proliferation, apoptosis and their abnormal expression levels are closely associated with pathogenesis of cancers. In this scenario, several high-throughput technologies studies have revealed miRNA roles in classifying tumors and predicting patient outcome with high accuracy. Because of their ability to concurrently target multiple pathways miRNA-based anticancer therapies are being developed, either alone or in combination with current targeted therapies, with the goal to improve the response and increase cure rates. Here, we highlight recent advances on the use of miRNAs as a potential approach for diagnosis and prognosis of solid cancer.

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Acknowledgements

Gianpiero Di Leva and Michela Garfolao researched data for the article and contributed to the writing, reviewing and editing of the manuscript. This work was supported in part by the Kimmel Cancer Award 2011 to Michela Garofalo.

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  1. Department of Molecular Immunology, Virology and Medical Genetics, Ohio State University, Biological Research Tower 992, 460 W 12th Avenue, Columbus, OH, 43210, USA

    Gianpiero Di Leva & Michela Garofalo

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  1. Gianpiero Di Leva
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  2. Michela Garofalo
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Correspondence to Michela Garofalo .

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  1. Dept. of Molec. Genetics, Fac. of Biological Sciences, Tarbiat Modares University, Tehran, Iran

    Sadegh Babashah

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Di Leva, G., Garofalo, M. (2014). MicroRNAs in Solid Tumors. In: Babashah, S. (eds) MicroRNAs: Key Regulators of Oncogenesis. Springer, Cham. https://doi.org/10.1007/978-3-319-03725-7_5

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