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The Biological Roles of MicroRNAs in Cancer Stem Cells

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MicroRNAs: Key Regulators of Oncogenesis

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Abstract

The concept of cancer stem cells (CSCs) has great clinical implications because small sub-populations of CSCs have been identified in many different tumors that are associated with poor clinical outcome. Sufficient evidence supports central functions of CSCs in tumorigenesis, due to its distinct high potentials of self-renewal, pluripotent differentiation and apoptosis-resistance, contributing to tumor aggressiveness. Therefore, inhibiting/eliminating CSCs will provide a new effective therapeutic approach for the treatment of aggressive tumors. However, the mechanistic roles of CSCs in tumorigenesis are not well understood. MicroRNAs (miRNAs) have been discovered to act as key regulators of gene expression in tumorigenesis. Aberrant expression of miRNAs has been discovered to be related to worse clinical outcome of many different tumors. Evidence shows that these tumor-related miRNAs have key functions in the regulation of cell cycle/proliferation, migration/invasion, chemo-radiation resistance, and metastasis. Moreover, miRNAs may also exert important functions in modulating CSC characteristics; however, its detailed mechanism(s) has not been fully elucidated. Here, we will summarize the potential role of CSC-related miRNAs in CSC function, and will further define the role of genistein in targeting these CSC-related miRNAs.

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Acknowledgements

We presented evidence as concisely as possible and during such effort we could not cite all the published data, and thus we sincerely apologize to those whose work could not be cited here.

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Authors and Affiliations

  1. Department of Pathology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    Bin Bao, Asfar S. Azmi, Aamir Ahmad, Yiwei Li, Sanjeev Banerjee, Dejuan Kong & Fazlul H. Sarkar

  2. Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA

    Shadan Ali & Fazlul H. Sarkar

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  1. Bin Bao
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  3. Aamir Ahmad
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Correspondence to Fazlul H. Sarkar .

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  1. Dept. of Molec. Genetics, Fac. of Biological Sciences, Tarbiat Modares University, Tehran, Iran

    Sadegh Babashah

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Bao, B. et al. (2014). The Biological Roles of MicroRNAs in Cancer Stem Cells. In: Babashah, S. (eds) MicroRNAs: Key Regulators of Oncogenesis. Springer, Cham. https://doi.org/10.1007/978-3-319-03725-7_12

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