Airflow and Particle Deposition in a Dry Powder Inhaler: An Integrated CFD Approach

  • Jovana Milenkovic
  • Alexandros H. Alexopoulos
  • Costas Kiparissides
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 256)

Abstract

An integrated computational model of a commercial Dry Powder Inhaler, DPI, device (i.e., Turbuhaler) is developed. The steady-state flow in a DPI is determined by solving the Navier-Stokes equations using FLUENT (v6.3) considering different flow models, e.g., laminar, k-ε, k-ω SST. Particle motion and deposition are described using an Eulerian-fluid/Lagrangian-particle approach. Particle/wall collisions are taken to result in deposition when the normal collision velocity is less than a size-dependent critical value. The flow rate and particle deposition are determined for a range of pressure drops (i.e., 800-8800Pa), as well as particle sizes corresponding to single particles and aggregates (i.e., 0.5-20μm). Overall, the simulation results are found to agree well with available experimental data for the volumetric outflow rate as well as the local and total particle deposition.

Keywords

Dry Powder Inhaler Turbuhaler CFD Particle Deposition 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Jovana Milenkovic
    • 1
    • 2
  • Alexandros H. Alexopoulos
    • 2
  • Costas Kiparissides
    • 1
    • 2
    • 3
  1. 1.Department of Chemical EngineeringAristotle University of ThessalonikiThessalonikiGreece
  2. 2.CPERI/CERTHThessalonikiGreece
  3. 3.Department of Chemical EngineeringThe Petroleum InstituteAbu DhabiU.A.E.

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