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Biological Effects of Ionizing Radiation

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Synopsis of Pathophysiology in Nuclear Medicine
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Abstract

The main tool in nuclear medicine is ionizing radiation; therefore, it is important for its users to be familiar with its biological effects and its pathophysiological basis. Ionization is the process of ion production by ejection of electrons from atoms and molecules after exposure to high temperature, electrical discharges, or electromagnetic and nuclear radiation. Ionizing radiation is subdivided into electromagnetic radiation (X-rays and gamma rays) and particulate radiation including neutrons and charged particles (alpha and beta particles).

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References

  1. United Nations Environment Program (1988) Radiation: doses, effects, risks. Blackwell, Oxford, pp 65–84

    Google Scholar 

  2. Cotran RS, Kumar V, Collins T (1999) Robbins pathologic basis of disease, 5th edn. Saunders, Philadelphia, pp 50–88

    Google Scholar 

  3. Prasad KN (1995) Handbook of radiobiology, 2nd edn. CRC Press, Boca Raton

    Google Scholar 

  4. Bolus NE (2001) Basic review of radiation biology and terminology. J Nucl Med Technol 29:67–73

    CAS  PubMed  Google Scholar 

  5. Ward JF (1988) DNA damage produced by ionizing radiation in mammalian cells: identities, mechanisms of formation, and reparability. Prog Nucleic Acid Res Mol Biol 35:95

    Article  CAS  PubMed  Google Scholar 

  6. Cohen BL (1995) Test of the linear-no threshold theory of radiation carcinogenesis in the low dose rate region. Health Phys 68:157

    Article  CAS  PubMed  Google Scholar 

  7. Holm I, Hall P, Wiklund K et al (1991) Cancer risk after iodine-131 therapy for hyperthyroidism. J Natl Cancer Inst 83:1072

    Article  CAS  PubMed  Google Scholar 

  8. Saenger EL, Thomas GE, Tompkins EA (1968) Incidence of leukemia following treatment of hyperthyroidism. Preliminary report of the cooperative thyrotoxicosis therapy follow-up study. JAMA 205:855

    Article  CAS  PubMed  Google Scholar 

  9. Matanoski GM, Tonascia JA, Correa-Villasenor A et al (2008). Cancer risks and low-level radiation in U.S. shipyard workers. J Radiat Res. 49:83–91

    Article  PubMed  Google Scholar 

  10. Cameron J (1992) The good news about low-level radiation exposure: health effects of low-level radiation in shipyard workers. Health Phys Soc Newslett 20:9

    Google Scholar 

  11. Billen D (1990) Spontaneous DNA damage and its significance for the “negligible dose”controversy in radiation protection. Radiat Res 124:242

    Article  CAS  PubMed  Google Scholar 

  12. Ward JF (1987) Radiation chemical methods of cell death. In: Fielden EM, Fowler JF, Hendry JH, Scott D (eds) Proceedings of the 8th international congress of radiation research, vol II. Taylor and Francis, London, p 162–168

    Google Scholar 

  13. Quingyi W (1993) DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc Natl Acad Sci U S A 90:1614

    Article  Google Scholar 

  14. Koshland DE, Sancar A, Hanawalt PC, Modrich P (1994) DNA repair enzymes and mechanisms. Science 266:1925–1927

    Article  CAS  PubMed  Google Scholar 

  15. Kneala GW, Stewart AM (1976) Mantel-Haenszel analysis of Oxford data. II. Independent effects of fetal irradiation subfactors. J Natl Cancer Inst 57:1009

    Google Scholar 

  16. Committee on the Biological Effects of Ionizing Radiations (1980) The effects on population of exposure to low levels of ionizing radiation. National Academic Press, Washington DC

    Google Scholar 

  17. International Commission on Radiological Protection (1969) Radiosensitivity and spatial distribution of dose, Publication no 14. Pergamon, Oxford

    Google Scholar 

  18. Dodo T (1975) Cataract. J Radiat Res 16(Suppl):132

    Article  PubMed  Google Scholar 

  19. United Nations Scientific Committee on the effects of atomic radiation (UNSCEAR 2008) (2010) Sources and effects of atomic radiation, vol. 1. United Nations publication, vienna

    Google Scholar 

  20. UNSCEAR (United Nations Scientific Committee on the Effects of Atomic Radiation) (1994) Annex B: adaptive responses to radiation in cells and organisms. Document A/Ac. 82/R.542, approved 11 March 1994

    Google Scholar 

  21. Johansson L (2003) Hormesis, an update of the present position. Eur J Nucl Med Mol Imaging 30:921–933

    Article  PubMed  Google Scholar 

  22. Feinendegen LE (2005) Low doses of ionizing radiation: relationship between biological benefit and damage induction. A Synopsis. World J Nucl Med 4:21–34

    Google Scholar 

  23. High Background radiation research group (1980) Health survey in high background radiation areas in China. Science 209:877–880

    Article  Google Scholar 

  24. Nambi KS, Soman SD (1987) Environmental radiation and cancer in India. Health Phys 52:653–657

    Article  CAS  PubMed  Google Scholar 

  25. Ghiassi-nejad M, Mortazavi SMJ, Cameron JR, Niroomand-Rad A, Karam PA (2002) Very high background radiation areas of Ramsar, Iran: preliminary biological studies. Health Phys 82:87–93

    Article  CAS  PubMed  Google Scholar 

  26. Jagger J (1998) Natural background radiation and cancer death in Rocky Mountain states and Gulf Coast states. Health Phys 75:428–430

    Article  CAS  PubMed  Google Scholar 

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Elgazzar, A.H. (2014). Biological Effects of Ionizing Radiation. In: Synopsis of Pathophysiology in Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-03458-4_15

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  • DOI: https://doi.org/10.1007/978-3-319-03458-4_15

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