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Nuclear Hematology

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Synopsis of Pathophysiology in Nuclear Medicine

Abstract

Nuclear hematology deals with the use of radionuclides or radiopharmaceutical agents in the study of the pathophysiology, diagnosis, and therapy of hematological diseases. Radionuclides are now widely used to label the formed elements of the blood (random labels) to trace their biological distribution, function, and life span in vivo as well as to study the proliferation and differentiation of hematopoietic progenitor and precursor cells in the bone marrow (cohort labels). The other major applications of nuclear hematology include the determination of spleen size, splenic sequestration of blood cells, and investigations relating to the absorption, metabolism, and utilization of hematopoietic nutrients such as iron, vitamin B12, and folate. This chapter reviews the pathophysiological basis of the important applications of radionuclides in the field of hematology.

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References

  1. Vogler JB, Murphy WA (1988) Bone marrow imaging. Radiology 168:679–693

    PubMed  Google Scholar 

  2. Dunnhill MS, Anderson JH, Whitehead R (1967) Quantitative histological studies on age changes in bone. J Pathol Bacteriol 94:275–291

    Article  Google Scholar 

  3. Hoffbrand AV, Lewis SM, Tuddenham EGD (1999) Postgraduate haematology, 4th edn. Butterworth-Heinemann, Oxford, pp 1–22, 327, 330, 334

    Google Scholar 

  4. Dacie JV, Lewis SM (1995) Erythrokinetics. In: Practical haematology, 8th edn. Churchill Livingstone, Edinburgh, pp 397–416

    Google Scholar 

  5. Ferrant A, Cauwe JL, Michaux C, Beckers C et al (1982) Assessment of the sites of red cell destruction using quantitative measurement of splenic and hepatic red cell destruction. Br J Haematol 50:591

    Article  CAS  PubMed  Google Scholar 

  6. Hoffbrand AV, Pettit JE (1993) Essential haematology, 3rd edn. Blackwell Science, Oxford, p 3, 4

    Google Scholar 

  7. Das KC (1995) Megaloblastosis a morphological expression of molecular derengements in DNA and histone biosynthesis. Immunohematol Bull 26:1–24

    Google Scholar 

  8. Das KC, Herbert V (1976) Vitamin B12-folate interrelationships. Clin Haematol 5:697–725

    CAS  PubMed  Google Scholar 

  9. Herbert V, Das KC (1976) The role of vitamin B12 and folic acid in haemato- and other cell poiesis. Vitam Horm 34:1–30

    Article  CAS  PubMed  Google Scholar 

  10. Das KC, Herbert V (1989) In vitro DNA synthesis by megaloblastic bone marrow. Am J Hematol 31:11–20

    Article  CAS  PubMed  Google Scholar 

  11. Zittoun J, Zittoun R (1999) Modern clinical testing strategies in cobalamin and folate deficiency. Semin Hematol 36:35–46

    CAS  PubMed  Google Scholar 

  12. Chanarin I (1979) Pernicious anaemia. In: Megaloblastic anaemias, 2nd edn. Blackwell Scientific, London, pp 316–331

    Google Scholar 

  13. Herbert V (1985) Biology of disease. Megaloblastic Anaemias. Lab Invest 52:3–19

    CAS  PubMed  Google Scholar 

  14. Lindenbaum J, Healton EB, Savage DB et al (1988) Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytes. N Engl J Med 318:1720–1728

    Article  CAS  PubMed  Google Scholar 

  15. Kanazawa S, Herbert V (1985) Total corrinoids, cobalamin (vitamin B12) and cobalamin analogue levels may be normal in serum despite cobalamin in liver depletion in patients with alcoholism. Lab Invest 53:108–110

    CAS  PubMed  Google Scholar 

  16. Kumar S, Ghosh K, Das KC (1989) Serum vitamin B12 in an Indian population: on evaluation of three assay methods. Med Lab Sci 46:487–492

    Google Scholar 

  17. Briedis D, McIntyre PA, Judisch J, Wagner HN Jr (1973) An evaluation of a dual- isotope method for the measurement of vitamin B12 absorption. J Nucl Med 14:135–141

    CAS  PubMed  Google Scholar 

  18. Krynycki BR, Zuckier LS (1995) An accuracy in using dual-isotope Schilling test to measure urine samples: a multicentric study. J Nucl Med 36:1659–1665

    Google Scholar 

  19. Belaiche J, Cattan D, Zittoun J et al (1983) Effects of ranitidine on cobalamin absorption. Dig Dis Sci 28:667–668

    Article  CAS  PubMed  Google Scholar 

  20. Carmel R (1992) Malabsorption of food folate. In: megaloblastic anaemia. Baillieres Clin Haematol 8:639–655

    Article  Google Scholar 

  21. Doscherholmen A, Swaim WR (1973) Impaired assimilation of egg 57Co-vitamin B12 in patients with hypochlorhydria and achlorhydria and after gastric resection. Gastroenterology 64:913–919

    CAS  PubMed  Google Scholar 

  22. Carmel R, Sinow RM, Siegel ME et al (1988) Food cobalamin malabsorption occurs frequently in patients with unexplained low serum cobalamin levels. Arch Intern Med 148:1715–1719

    Article  CAS  PubMed  Google Scholar 

  23. Karnaze DS, Carmel R (1990) Neurologic and evoked potential abnormalities in subtle cobalamin deficiency states, including deficiency without anemia and normal absorption of free cobalamin. Arch Neurol 47:1008–1012

    Article  CAS  PubMed  Google Scholar 

  24. Chapman WC, Newman M (1999) Disorders of the spleen. In: Lee GR (ed) Wintrobe’s clinical hematology, vol 2, 10th edn. Williams and Wilkins, Baltimore, pp 1969–1989

    Google Scholar 

  25. Ferrant A, Leners N, Michaux JL et al (1987) The spleen and hemolysis: evaluation of the intrasplenic transit time. Br J Hematol 65:31–34

    Article  CAS  Google Scholar 

  26. Sheldon GF, Croom RD III, Meyer AA (1991) The spleen. In: Sabeston DC Jr (ed) Textbook of surgery, 14th edn. Saunders, Philadelphia, pp 1108–1133

    Google Scholar 

  27. Bannester LH (1995) Haemolymphoid system. In: Bannester LH (ed) Gray’s anatomy, 38th edn. Churchill Livingstone, New York, pp 1399–1442

    Google Scholar 

  28. Bohnsack JF, Brown EJ (1986) The role of spleen in resistance to infection. Annu Rev Med 37:49–59

    Article  CAS  PubMed  Google Scholar 

  29. Garewal G, Narang A, Das KC (1988) Infantile tremor syndrome: a vitamin B12 deficiency syndrome in infants. J Trop Pediatr 34:174–178

    Article  CAS  PubMed  Google Scholar 

  30. Spirer Z, Zakuth V, Tzehoval E et al (1980) Tuftsin stimulates IL-1 production by human mononuclear cells, human spleen cells and mouse spleen cells in vitro. J Clin Lab Immunol 28:27–31

    Google Scholar 

  31. Pabst R, Westemann J (1991) The role of the spleen in lymphocyte migration. Scan Micro 5:1075–1079

    CAS  Google Scholar 

  32. Toft P, Tonnesen E, Helbo-Hansen HS et al (1994) Redistribution of granulocytes in patients after major surgical stress. APMIS 102:43–48

    Article  CAS  PubMed  Google Scholar 

  33. Kim CK, Reske SN, Alavi A (1996) Bone marrow scintigraphy. In: Honkin RE, Boles MA, Dillehag GL et al (eds) Nuclear medicine, vol I. Mosby, St.Louis, pp 1223–1249

    Google Scholar 

  34. Desai AG, Thakur ML (1985) Radiopharmaceuticals for spleen and bone marrow studies. Semin Nucl Med 15:229–238

    Article  CAS  PubMed  Google Scholar 

  35. Datz FL, Taylor A Jr (1985) The clinical use of radionuclide bone marrow imaging. Semin Nucl Med 15:239–259

    Article  CAS  PubMed  Google Scholar 

  36. Mishkin FS, Freeman LM (1984) Miscellaneous application of radionuclide imaging: bone marrow. In: Freeman LM (ed) Freeman and Johnson’s radionuclide imaging, 2nd edn. Grune& Stratton, Orlando

    Google Scholar 

  37. Van Dyke D, Shkurkin C, Price D et al (1967) Differences in distribution of erythropoietic and reticuloendothelial marrow in hematologic disease. Blood 30:364–374

    PubMed  Google Scholar 

  38. Reske SN, Buell U (1990) Reduced technetium-99m labelled NCA-95/CEA antibodies (TcNCAA) for immunoscintigraphy of hematopoietic bone marrow in man. Antibody distribution in normal bone marrow. In: Hofer A, Bergmann H (eds) Radioactive Isotope in Klinik und Forschung. Schattauer, Stuttgart

    Google Scholar 

  39. Reske SN, Karstens JH, Gloeckner W et al (1989) Radioimmunoimaging for diagnosis of bone marrow involvement in breast cancer and malignant lymphoma. Lancet 1:299–301

    Article  CAS  PubMed  Google Scholar 

  40. Reske SN, Sohn M, Karstens JH et al (1990) Immunoscintigraphy of bone marrow with Tc-99m labelled NCA-95/CEA antibodies (TcNCAA). Comparison with bone scanning, plain radiographs and HAMA response. J Nucl Med 31:751

    Google Scholar 

  41. Chipping P, Klonizakis I, Lewis SM (1980) Indium chloride scanning; a comparison with iron as a tracer for erythropoiesis. Clin Lab Haematol 2:255–263

    Article  Google Scholar 

  42. Axelsson B, Kalin B (1990) Comparison of 111- In granulocytes and Tc-99m albumin colloid for bone marrow scintigraphy by the use of quantitative SPECT imaging. Clin Nucl Med 15:473–479

    Article  CAS  PubMed  Google Scholar 

  43. Aburano T, Yokoyama K, Shuke N et al (1992) Tc-99m HMPAO-labeled leukocytes for hematopoietic marrow imaging. Comparison with In-III chloride. Clin Nucl Med 17:938–944

    Article  CAS  PubMed  Google Scholar 

  44. Palestro C, Charalel J, Vallabhajosula S et al (1987) In-WBC as a bone marrow imaging agent. J Nucl Med 28:574

    Google Scholar 

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Authors and Affiliations

  1. Department of Nuclear Medicine, Kuwait University, Safat, Kuwait

    Abdelhamid H. Elgazzar

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  1. Abdelhamid H. Elgazzar
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© 2014 Springer International Publishing Switzerland

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Elgazzar, A.H. (2014). Nuclear Hematology. In: Synopsis of Pathophysiology in Nuclear Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-03458-4_13

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  • DOI: https://doi.org/10.1007/978-3-319-03458-4_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-03457-7

  • Online ISBN: 978-3-319-03458-4

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