Quantifying Effect of Blood Pressure on Stress Distribution in Atherosclerotic Plaque

  • Lina Pu
  • Huahua Xiong
  • Xin Liu
  • Heye Zhang
  • Yuan-Ting Zhang
Conference paper
Part of the IFMBE Proceedings book series (IFMBE, volume 42)

Abstract

Plaque rupture and its ensuing thrombosis have been one of major causes of acute ischemic events relating to atherosclerosis. Therefore, it is important to make an early assessment of the plaque vulnerability and then perform a timely intervention to decrease or avoid the acute life threatening events. Many studies have been proposed to simulate the stress distribution in the atherosclerotic plaque using computational mechanical analysis. Most of the studies were focused on how the blood fluid velocity, plaque component/ size/shape, etc. affect the plaque vulnerability. Blood pressure (BP) has been a well-known screening factor for cardiovascular events, but the effect of BP on the stress distribution in the plaque has not been examined in depth before. In this study, the simulation was performed to investigate the variation of stress in plaque and maximum blood velocity with varying BP, as well as the differential pressure between the pressure input and output the vessel (ΔP). Under the same value of ΔP before and after the maximum ΔP, the stresses in the plaque corresponding to ΔP of descent phase were greater than that of ascent phase. The results of the study indicated that increased ΔP might cause not only the immediate increscent stress but also the slight increase to the following stress in plaque.

Keywords

Atherosclerotic Plaque vulnerability Stress distribution Blood Pressure Computational mechanical analysis 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Lina Pu
    • 1
    • 2
  • Huahua Xiong
    • 3
  • Xin Liu
    • 1
    • 2
  • Heye Zhang
    • 1
    • 2
  • Yuan-Ting Zhang
    • 1
    • 2
    • 4
  1. 1.Key Lab of Health InformaticsChinese Academy of SciencesShenzhenChina
  2. 2.Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyShenzhenChina
  3. 3.Department of UltrasoundThe Second People’s Hospital of ShenzhenShenzhenChina
  4. 4.Joint Research Centre for Biomedical EngineeringThe Chinese University of Hong KongShatinHong Kong

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