Cavitation Endothelium Damage of Large Artery Vessel: A Potential Application to Animal Model of Atherosclerosis

  • Y. J. Zong
  • J. J. Wan
  • Y. Z. Qiao
  • W. S. Li
  • X. R. Zou
  • M. X. Wan
Part of the IFMBE Proceedings book series (IFMBE, volume 42)

Abstract

Mechanical arterial balloon injury combined with hypercholesterolemia is the most widely and frequently employed method to induce atherosclerosis in animal models. But it is not suitable to generate a localized eccentric plaque at a specific site. In this paper, experiments were conducted to confirm whether focused ultrasound (FU) induced cavitation could cause endothelium lesion in rabbit abdominal aorta and thereby became an alternative approach to induce atherosclerosis. The cavitation damages induced by commercial microbubbles and phase-shifted nanodroplets under focused ultrasound exposure in wall-less vessel phantom and isolated rabbit abdominal aorta segment were studied. The results will provide a potential strategy to develop a localized atherosclerosis model at specific site by using FU cavitation induced endothelium damage.

Keywords

Cavitation microbubbles endothelium damage atherosclerosis abdominal aorta phase-shift nanodroplets 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Y. J. Zong
    • 1
  • J. J. Wan
    • 1
  • Y. Z. Qiao
    • 1
  • W. S. Li
    • 1
  • X. R. Zou
    • 1
  • M. X. Wan
    • 1
  1. 1.The Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical EngineeringXi’an Jiaotong UniversityXi’anPeople’s Republic of China

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