Innovative Immunosensors for Early Stage Cancer Diagnosis and Therapy Monitoring

  • Cecilia Cristea
  • Anca Florea
  • Ramona Galatus
  • Ede Bodoki
  • Robert Sandulescu
  • Daniel Moga
  • Dorin Petreus
Part of the IFMBE Proceedings book series (IFMBE, volume 42)

Abstract

This paper addresses the development of a diagnosis device based on optical and electrochemical principles for the detecting the levels of multiple mucin (MUC) type biomarkers. Combining surface plasmon resonance (SPR) and electrochemical techniques the selectivity can lead to improved sensitivity and reliability of the obtained transducer. The structures appropriate for an easy operated device, not requiring highly skilled operating personnel or expensive instrumentation, while offering fast, selective and accurate analytical response are investigated. A diagnosis device based on such combined immunosensor can greatly improve the chances of early diagnosis of ovarian cancer.

Keywords

electrochemical immunosensor SPR phenomenon antibody aptamer gold nanoparticles 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Cecilia Cristea
    • 1
  • Anca Florea
    • 1
  • Ramona Galatus
    • 2
  • Ede Bodoki
    • 1
  • Robert Sandulescu
    • 1
  • Daniel Moga
    • 2
  • Dorin Petreus
    • 2
  1. 1.Faculty of Pharmacy, Analytical Chemistry Department“Iuliu Haţieganu” University of Medicine and Pharmacy Cluj-NapocaCluj-NapocaRomania
  2. 2.Technical University of Cluj-NapocaCluj-NapocaRomania

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