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Physiological Diagnosis and Rehabilitation for the Alzheimer Type Dementia

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Book cover Brain and Health Informatics (BHI 2013)

Part of the book series: Lecture Notes in Computer Science ((LNAI,volume 8211))

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Abstract

Light reflex and oculogyration analysing system is proposed in order to diagnose the Alzheimer type dementia (DAT) objectively. 19 patients are studied, which shows that the maximum miosis ratio and miosis velocity are sensitive parameters to evaluate the severity of dementia and the changing time of internal and external rectus eye muscles is the effective index for screening of the dementia. The threshold of the changing time over 0.35 second can discriminate DAT clearly from the normal. Biofeedback trainings of the demented are executed by the objective diagnosing method, which shows improvement in MMSE, ADL score and the eye reflex parameters. The proposed method may become a safe non-pharmacological treatment of the dementia.

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References

  1. Sekuler, R., Hutman, L.P., Owsley, C.J.: Human aging and spatial vision. Science 209, 1255–1256 (1980)

    Article  Google Scholar 

  2. Jones, A., Friedland, R.P., et al.: Saccadic intrusions in Alzheimer-type dementia. J. Neurol. 229, 189–194 (1983)

    Article  Google Scholar 

  3. Hutton, J.T., Nagel, J.A., Loewenson, R.B.: Eye tracking dysfunction in Alzheimer-type dementia. Neurology 34, 99–102 (1984)

    Article  Google Scholar 

  4. Lisberger, S.G., Morris, E.J., Tychsen, L.: Visual motion processing and sensory-motor integration for smooth pursuit eye movements. Annual Review Neuro-Science 10, 97–129 (1987)

    Google Scholar 

  5. Robinson, D.A., Gordon, J.L., Gordon, S.E.: A model of the smooth pursuit eye movement system. Biological Cybernetics 55, 43–57 (1988)

    Article  Google Scholar 

  6. Fletcher, W.A., Sharpe, J.A.: Smooth pursuit dysfunction in Alzheimer’s disease. Neurology 38, 272–277 (1988)

    Article  Google Scholar 

  7. Mendez, M.F., Tomsak, R.L., Remler, B.: Disorders of the Visual System in Alzheimer’s disease. J. Clinical Neuro-ophthalmology 10(1), 62–69 (1990)

    Google Scholar 

  8. Trick, G.L., Silverman, S.E.: Visual sensitivity to motion: Age-related changes and deficits in senile dementia of the Alzheimer type. Neurology 41, 1437–1440 (1991)

    Article  Google Scholar 

  9. Cronin-Golomb, A., Corkin, S., et al.: Visual Dysfunction in Alzheimer’s disease: Relation to Normal Age. Annals of Neurology 29(1), 41–52 (1991)

    Article  Google Scholar 

  10. Müller, G., Richter, R.A., et al.: Impaired eye tracking performance in patients with presenile onset dementia. Int. J. Psychophysiolol. 11, 167–177 (1991)

    Article  Google Scholar 

  11. Zaccara, G., Gangemi, P.F., et al.: Smooth-pursuit eye movements: alterations in Alzheimer’s disease. J. Neurological Sciences 112, 81–89 (1992)

    Article  Google Scholar 

  12. Scinto, L.F.M., Daffner, K.R., Castro, L., Weintraub, S., Vavrik, M., Mesulam, M.M.: Impairment of spatially directed attention in patients with probable Alzheimer’s disease as measured by eye movements. Arch. Neurol. 1, 682–688 (1994)

    Article  Google Scholar 

  13. Paasuraman, R., Greenwood, P.M., Alexander, G.E.: Selective impairment of spatial attention during visual search in Alzheimer’s disease. Cognitive Neuroscience and Neuropsychology, Neuro Report 6 6(14), 1861–1864 (1995)

    Google Scholar 

  14. Moser, A., Kömpf, D., Olschinka, J.: Eye moverment dysfunction in Dementia of the Alzheimer type. Dementia 6, 264–268 (1995)

    Google Scholar 

  15. Shi, X., Utiyama, H., Fukumoto, I.: A study for diagnose dementia using miosis by light-reflex. In: International Symposium on Dementia – from Molecular Biology to Therapeutics, Kobe, September 11-13, p. 46 (1999)

    Google Scholar 

  16. Fukumoto, I.: A computer simulation of the new diagnosing method by human eye light-reflexes. In: Proceedings of IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering (APBME 2000), September 26, pp. 624–625 (2000)

    Google Scholar 

  17. Shi, X., Guo, Y., Uchiyama, H., Fukumoto, I.: A Study for a new Diagnostic and Rehabilitation method for Dementia Using miosis by Light-Reflex. In: Proceedings of IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering (APBME 2000), September 28, pp. 505–506 (2000)

    Google Scholar 

  18. Fukushima, S., Shi, X., Tuchida, Y., Guo, Y., Uchiyama, H., Fukumoto, I., Suzuki, K., Murakami, S., Nakajima, R.: A new objective approach to diagnose dementia by pupillary light reflex method. In: Proceedings of IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering (APBME 2000), September 28, pp. 716–717 (2000)

    Google Scholar 

  19. Rösler, A., Mapstone, M.E., Hays, A.K., Mesulam, M.M., Rademaker, A.: Alterations of Visual Search Strategy in Alzheimer’s Disease and Aging. Neuropsychology 14(3), 398–408 (2000)

    Article  Google Scholar 

  20. Lueck, K.L., Mendez, M.F., Perryman, K.M.: Eye movement abnormalities during reading in patients with Alzheimer disease. Neuropsychiatry, Neuropsychology and Behavioral Neurology 13(2), 77–82 (2000)

    Google Scholar 

  21. Fukumoto, I.: A computer simulation of the new diagnosing method by human eye light-reflexes. In: Proceedings of IEEE-EMBS Asia-Pacific Conference on Biomedical Engineering (APBME 2000), Hanzhou, September 26, pp. 624–625 (2000)

    Google Scholar 

  22. Fukumoto, I.: A basic study for the new dementia diagnostic system using human eye light reflex. In: Proceeding of the International Workshop on Gerontechnology, Tsukuba, March 13-16, pp. 93–94 (2001)

    Google Scholar 

  23. Fukumoto, I.: Computer aided diagnosis for the Alzheimer type dementia. In: Niessen, W., Viergever, M. (eds.) MICCAI 2001. LNCS, vol. 2208, pp. 1386–1387. Springer, Heidelberg (2001)

    Chapter  Google Scholar 

  24. Fukumoto, I.: A computer diagnosing system of dementia using smooth pursuit oculogyration. In: Dohi, T., Kikinis, R. (eds.) MICCAI 2002, Part I. LNCS, vol. 2488, pp. 674–681. Springer, Heidelberg (2002)

    Chapter  Google Scholar 

  25. Fukumoto, I.: New diagnosing system for the automatic screening of Alzheimer type dementia by human eye reflexes. In: Proc. of Int. Cong. on Biological and Medical Engineering, D1VB-1230, Singapore (December 2002)

    Google Scholar 

  26. Guo, Y., Shi, X., Uchiyama, H., Hasegawa, A., Nakagawa, Y., Tanaka, M., Fukumoto, I.: A study of the rehabilitation of cognitive function and short-term memory in patients with Alzheimer’s disease using transcutaneous electrical nerve stimulation. Frontiers Med. Biol. Engng. 11(4), 237–247 (2002)

    Article  Google Scholar 

  27. Fukumoto, I.: A study of physiological diagnosing system for Alzheimer type dementia by oculomotor dysfunction. In: The Congress Proceedings of World Congress on Medical Physics and Biomedical Engineering, Sydney, August 24-29 (2003)

    Google Scholar 

  28. Fukumoto, I., Guo, Y., Hasegawa, J., Shi, X.: Rehabilitation systems of Alzheimer type dementia by somatic stimulations. Transactions of the Japanese Society for Medical and Biological Engineering, 665 (April 25-27, 2005)

    Google Scholar 

  29. Fukumoto, I.: A Unified Model of the Alzheimer-Dementia and Parkinsonian-Disease Based on the Somatic Stimulation Effects. In: WC 2006 Program Book, Seoul, pp. 125–128 (August 2006)

    Google Scholar 

  30. Fukumoto, I.: A Study for physiological diagnosis and non-pharmacological treatment of the Alzheimer type dementia. In: Healthinf 2011 (2011)

    Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Biomedical Engineeing, Nagaoka Universit of Technology, Kamitomioka 1603-1, Nagaoka city, Japan

    Ichiro Fukumoto

Authors
  1. Ichiro Fukumoto
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Editor information

Editors and Affiliations

  1. Department of Systems Life Engineering, Maebashi Institute of Technology, 460-1 Kamisadori-cho, 371-0816, Maebashi, Gunma, Japan

    Kazayuki Imamura

  2. Electronics-Inspired Interdisciplinary Research Institute, Toyohashi University of Technology, 1-1 Hibarigaoka Tenpaku-cho, 441-8580, Toyohashi, Aichi, Japan

    Shiro Usui

  3. Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, 39-22 Showamachi 3-chome, 371-8511, Maebashi, Gunma, Japan

    Tomoaki Shirao

  4. The Smith Kettlewell Eye Research Institute, 2318 Fillmore Street, 94115, San Francisco, CA, USA

    Takuji Kasamatsu

  5. University of Rostock, 18051, Rostock, Germany

    Lars Schwabe

  6. Department of Life Science and Informatics, Maebashi Institute of Technology, 460-1 Kamisadori-cho, 371-0816, Maebashi, Gunma, Japan

    Ning Zhong

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Fukumoto, I. (2013). Physiological Diagnosis and Rehabilitation for the Alzheimer Type Dementia. In: Imamura, K., Usui, S., Shirao, T., Kasamatsu, T., Schwabe, L., Zhong, N. (eds) Brain and Health Informatics. BHI 2013. Lecture Notes in Computer Science(), vol 8211. Springer, Cham. https://doi.org/10.1007/978-3-319-02753-1_33

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  • DOI: https://doi.org/10.1007/978-3-319-02753-1_33

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-02752-4

  • Online ISBN: 978-3-319-02753-1

  • eBook Packages: Computer ScienceComputer Science (R0)

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