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Antibodies to Short Synthetic Acinetobacter and Pseudomonas Peptide Sequences Resembling Myelin and Neurofilaments in Multiple Sclerosis Patients

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Multiple Sclerosis, Mad Cow Disease and Acinetobacter
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Abstract

Peptide sequences of myelin basic protein and neurofilaments are relevant in the study of these epitopes for their role in the aetiology of multiple sclerosis.

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References

  • Amor S, Groome N, Linington C, Morris MM, Dornmair K, Gardiner MV, Matthieu JM, Baker D. Identification of epitopes of myelin oligodendrocyte glycoprotein for the induction of experimental allergic encephalomyelitis in SJL and Biozzi AB/H mice. J Immunol. 1994;153:4349–56.

    CAS  PubMed  Google Scholar 

  • Ben-Nun A, Otmy H, Cohen IR. Genetic control of autoimmune encephalomyelitis and recognition of the critical nonapeptide moiety of myelin basic protein in guinea pigs are exerted through interaction of lymphocytes and macrophages. Eur J Immunol. 1981;11:311–6.

    Article  CAS  PubMed  Google Scholar 

  • Correale J, de los Milagros Bassani Molinas M. Time course of T-cell responses to MOG and MBP in patients with clinically isolated syndromes. J Neuroimmunol. 2003;136:162–71.

    Article  CAS  PubMed  Google Scholar 

  • Edwards S, Zvartau M, Clarke H, Irving W, Blumhardt LD. Clinical relapses and disease activity on magnetic resonance imaging associated with viral upper respiratory tract infections in multiple sclerosis. J Neurol Neurosurg Psychiatry. 1998;64:736–41.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Granieri E, Casetta I, Tola MR, Ferrante P. Multiple sclerosis: infectious hypothesis. Neurol Sci. 2001;22:179–85.

    Article  CAS  PubMed  Google Scholar 

  • Haase CG, Guggenmos J, Brehm U, Andersson M, Olsson T, Reindl M, Schneidewind JM, Zent UK, Heidenreich F, Berger T, Wekerle H, Hohlfield R, Linington C. The fine specicity of the myelin oligodendrocyte glycoprotein autoantibody response in patients with multiple sclerosis and normal healthy controls. J Neuroimmunol. 2001;114:220–5.

    Article  CAS  PubMed  Google Scholar 

  • Hughes LE, Smith PA, Bonell S, Natt RS, Wilson C, Rashid T, Amor S, Thompson EJ, Croker J, Ebringer A. Cross-reactivity between related sequences found in Acinetobacter sp., Pseudomonas aeruginosa, myelin basic protein and myelin oligodendrocyte glycoprotein in multiple sclerosis. J Neuroimmunol. 2003;144:105–15.

    Article  CAS  PubMed  Google Scholar 

  • Kennel de March A, De Bouwerie M, Kolopp-Sarda MM, Faure GC, Bene MC, Bernard CC. Anti-myelin oligodendrocyte glycoprotein B-cell responses in multiple sclerosis. J Neuroimmunol. 2003;135:117–25.

    Article  CAS  PubMed  Google Scholar 

  • Kerlero de Rosbo N, Hoffman M, Mendel I, Yust I, Kaye J, Bakimer R, Flechter S, Abramsky O, Milo R, Karni A, Ben-Nunn A. Predominance of the autoimmune response to myelin oligodendrocyte glycoprotein (MOG) in multiple sclerosis: reactivity to the extracellular domain of MOG is directed against three main regions. Eur J Immunol. 1997;27:3059–69.

    Article  CAS  PubMed  Google Scholar 

  • Kohm AP, Fuller KG, Miller SD. Mimicking the way to autoimmunity: an evolving theory of immune sequence and structural homology. Trends Microbiol. 2003;11:101–5.

    Article  CAS  PubMed  Google Scholar 

  • Mazza G, Ponsford M, Lowrey P, Campbell MJ, Zajicek J, Wraith DC. Diversity and dynamics of the T cell reponse to myelin basic protein in DR + individuals. Clin Exp Immunol. 2002;128:538–47.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  • Rapp NS, Gilroy J, Lerner AM. Role of bacterial infection in exacerbation of multiple sclerosis. Am J Phys Med Rehabil. 1995;74:415–8.

    Article  CAS  PubMed  Google Scholar 

  • Salvetti M, Ristori G, D’Amato M, Buttinelli C, Falcone M, Fieschi C, Wekerle H, Pozzilli C. Predominant and stable T cell responses to regions of myelin basic protein can be detected in individual patients with multiple sclerosis. Eur J Immunol. 1993;23:1232–9.

    Article  CAS  PubMed  Google Scholar 

  • Steinman L. Multiple sclerosis: a two stage disease. Nat Immunol. 2001;2:762–4.

    Article  CAS  PubMed  Google Scholar 

  • Stepaniak JA, Wolff NA, Sun D, Swanborg RH. Interstrain variability of autoimmune encephalomyelitis in rats: multiple encephalitogenic myelin basic protein epitopes for DA rats. J Neuroimmunol. 1997;78:79–85.

    Article  CAS  PubMed  Google Scholar 

  • Talbot PJ, Arnold D, Antel JP. Virus induced autoimmune reactions in the CNS. Curr Top Microbiol Immunol. 2001;253:247–71.

    CAS  PubMed  Google Scholar 

  • Tejada-Simon MV, Zang YC, Hong J, Rivera VM, Zhang JZ. Cross-reactivity with myelin basic protein and human Herpes virus-6 in multiple sclerosis. Ann Neurol. 2003;53:189–97.

    Article  CAS  PubMed  Google Scholar 

  • Villers D, Espaze E, Coste-Burel M, Giauffret F, Ninin E, Nicolas F, Richet H. Nosocomial Acinetobacter baumannii infections: microbiological and clinical epidemiology. Ann Intern Med. 1998;129:182–9.

    Article  CAS  PubMed  Google Scholar 

  • Wajgt A, Gorny M. CSF antibodies to myelin basic protein and to myelin-associated glycoprotein in multiple sclerosis. Evidence of the intrathecal production of antibodies. Acta Neurol Scand. 1983;68:337–43.

    Article  CAS  PubMed  Google Scholar 

  • Warren KG, Catz I. Specificity of tissue-CSF bound anti-myelin basic protein in multiple sclerosis. J Neuroimmunol. 1997;43:87–96.

    Article  Google Scholar 

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Ebringer, A. (2015). Antibodies to Short Synthetic Acinetobacter and Pseudomonas Peptide Sequences Resembling Myelin and Neurofilaments in Multiple Sclerosis Patients. In: Multiple Sclerosis, Mad Cow Disease and Acinetobacter. Springer, Cham. https://doi.org/10.1007/978-3-319-02735-7_14

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