Cortical Surface Analysis of Multi-contrast MR Data to Improve Detection of Cortical Pathology in Multiple Sclerosis

  • Marika Archambault-Wallenburg
  • Douglas Arnold
  • Sridar Narayanan
  • G. Bruce Pike
  • D. Louis Collins
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8159)


Cortical multiple sclerosis (MS) lesions are very hard to detect on magnetic resonance images, even though histopathology studies reveal that their extent can be important. Certain pulse sequences are known to help detect the lesions, but this detection is still very incomplete. To aid detection, we propose to use a cortical surface-based analysis of multi-contrast MR data in MS and healthy control subjects. We show that magnetization transfer ratio and T1-weighted scans both show differences at the group level between relapsing-remitting MS patients and healthy controls. This suggests that this approach would be useful to help detect cortical pathology in MS.


Laminar profile cortex multiple sclerosis intensity standardization 


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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Marika Archambault-Wallenburg
    • 1
  • Douglas Arnold
    • 1
  • Sridar Narayanan
    • 1
  • G. Bruce Pike
    • 1
  • D. Louis Collins
    • 1
  1. 1.Montreal Neurological InstituteMcGill UniversityMontrealCanada

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