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Polyelectrolyte Hydrogels: Thermodynamics

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Polyelectrolytes

Part of the book series: Engineering Materials ((ENG.MAT.))

Abstract

Polyelectrolyte hydrogel is a three dimensional networks forming by charged polymer chains. The hydrophilic networks capable of imbibing large amount of water or biological fluids, mimics biological tissues. Because of this nature, great attention was devoted to these systems for biomedical applications by tuning the physicochemical properties with varying the degree of crosslinking either by physical or chemical or physical-chemical means. Numerous approaches have been investigated for formulation of polyelectrolyte hydrogels. In this chapter, an attempt was made to narrate the synthetic and natural materials and their mechanism to form cross-linked polyelectrolyte hydrogels. It was also tried to explain the importance of ionotropic gelation and polyelectrolyte complexation approaches, as these methods show great promise as a tool for the development in their application process. For further understanding in this area, a mathematical model was introduced to describe the thermodynamic behavior of polyelectrolyte hydrogels and derives conditions for thermodynamic phase equilibrium; the physical and chemical characterization of hydrogels, as well as special considerations that need to be made when characterizing polyelectrolyte hydrogels, were also discussed. In the end, a number of biomedical applications of polyelectrolyte hydrogel were given, such as in controlled release systems, different types of tissue reconstitution, for the enzyme and protein separations, etc.

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References

  1. Osada, Y., Gong, J.P.: Adv. Mater. 10, 827 (1998)

    Google Scholar 

  2. Nisato, G., Munch, J.P., Candau, S.J.: Langmuir 15, 4236 (1999)

    Google Scholar 

  3. Pafiti, K.S., Philippou, Z., Loizou, E., Porcar, L., Patrickios, C.S.: Macromolecules 44, 5352 (2011)

    Google Scholar 

  4. Takeoka, Y., Berker, A.N., Du, R., Enoki, T., Grosberg, A., Kardar, M., Oya, T., Tanaka, K., Wang, G.Q., Yu, X.H., Tanaka, T.: Phys. Rev. Lett. 82, 4863 (1999)

    Google Scholar 

  5. Firestone, B.A., Siegel, R.A.: J. Appl. Polym. Sci. 43, 901 (1991)

    Google Scholar 

  6. Tanaka, T., Nishio, I., Sun, S.T., Uenonishio, S.: Science 218, 467 (1982)

    Google Scholar 

  7. Mohammadi, A.: Phys. Fluids , 25 (2013)

    Google Scholar 

  8. Ito, Y., Casolaro, M., Kono, K., Imanishi, Y.: J. Controlled Release 10, 195 (1989)

    Google Scholar 

  9. Miyata, T., Uragami, T., Nakamae, K.: Adv. Drug Deliv. Rev. 54, 79 (2002)

    Google Scholar 

  10. Beebe, D.J., Moore, J.S., Bauer, J.M., Yu, Q., Liu, R.H., Devadoss, C., Jo, B.H.: Nature 404, 588 (2000)

    Google Scholar 

  11. Richter, A., Paschew, G., Klatt, S., Lienig, J., Arndt, K.F., Adler, H.J.P.: Sensors 8, 561 (2008)

    Google Scholar 

  12. Nagase, K., Kobayashi, J., Okano, T.: J. R. Soc. Interface 6, S293 (2009)

    Google Scholar 

  13. Seliktar, D.: Science 336, 1124 (2012)

    Google Scholar 

  14. Stuart, M.A.C., Huck, W.T.S., Genzer, J., Muller, M., Ober, C., Stamm, M., Sukhorukov, G.B., Szleifer, I., Tsukruk, V.V., Urban, M., Winnik, F., Zauscher, S., Luzinov, I., Minko, S.: Nat. Mater. 9, 101 (2010)

    Google Scholar 

  15. Liu, L., Wang, W., Ju, X.J., Xie, R., Chu, L.Y.: Soft Matter 6, 3759 (2010)

    Google Scholar 

  16. Sun, T.L., Kurokawa, T., Kuroda, S., Bin Ihsan, A., Akasaki, T., Sato, K., Haque, M.A., Nakajima, T., Gong, J.P.: Nat. Mater. 12, 932 (2013)

    Google Scholar 

  17. Torres-Lugo, M., Peppas, N.A.: Macromolecules 32, 6646 (1999)

    Google Scholar 

  18. Kim, B., Peppas, N.A.: Biomed. Microdevices 5, 333 (2003)

    Google Scholar 

  19. Sawahata, K., Hara, M., Yasunaga, H., Osada, Y.: J. Controlled Release 14, 253 (1990)

    Google Scholar 

  20. Kost, J., Horbett, T.A., Ratner, B.D., Singh, M.: J. Biomed. Mater. Res. 19, 1117 (1985)

    Google Scholar 

  21. Ishihara, K., Kobayashi, M., Ishimaru, N., Shinohara, I.: Polym. J. 16, 625 (1984)

    Google Scholar 

  22. Ramkissoon-Ganorkar, C., Baudys, M., Kim, S.W.: J. Biomater. Sci. Polym. Ed. 11, 45 (2000)

    Google Scholar 

  23. Markland, P., Zhang, Y.H., Amidon, G.L., Yang, V.C.: J. Biomed. Mater. Res. 47, 595 (1999)

    Google Scholar 

  24. Hynes, S.R., Mcgregor, L.M., Rauch, M.F., Lavik, E.B.: J. Biomater. Sci. Polym. Ed. 2007, 18 (1017)

    Google Scholar 

  25. Chiu, H.C., Hsiue, G.H., Lee, Y.P., Huang, L.W.: J. Biomater. Sci. Polym. Ed. 10, 591 (1999)

    Google Scholar 

  26. Leach, J.B., Bivens, K.A., Patrick, C.W., Schmidt, C.E.: Biotechnol. Bioeng. 82, 578 (2003)

    Google Scholar 

  27. Ramamurthi, A., Vesely, I.: J. Biomed. Mater. Res., Part A 66A, 317 (2003)

    Google Scholar 

  28. Drury, J.L., Mooney, D.J.: Biomaterials 24, 4337 (2003)

    Google Scholar 

  29. Brandl, F., Sommer, F., Goepferich, A.: Biomaterials 28, 134 (2007)

    Google Scholar 

  30. Qi, H., Ghodousi, M., Du, Y., Grun, C., Bae, H., Yin, P., Khademhosseini, A.: Nat. Commun. 4(2013)

    Google Scholar 

  31. Jin, R., Teixeira, L.S.M., Krouwels, A., Dijkstra, P.J., van Blitterswijk, C.A., Karperien, M., Feijen, J.: Acta Biomater. 2010, 6 (1968)

    Google Scholar 

  32. Li, F., Griffith, M., Li, Z., Tanodekaew, S., Sheardown, H., Hakim, M., Carlsson, D.J.: Biomaterials 26, 3093 (2005)

    Google Scholar 

  33. Wang, C., Stewart, R.J., Kopecek, J.: Nature 397, 417 (1999)

    Google Scholar 

  34. Chen, J.P., Cheng, T.H.: Macromol. Biosci. 2006, 6 (1026)

    Google Scholar 

  35. Tan, H.P., Ramirez, C.M., Miljkovic, N., Li, H., Rubin, J.P., Marra, K.G.: Biomaterials 30, 6844 (2009)

    Google Scholar 

  36. Kim, S.J., Yoon, S.G., Kim, I.Y., Lee, Y.H., An, K.H., Kim, N.G., Hong, C.U.: Smart Sensors, Actuators, and Mems, Pts 1 and 2, 5116, 756 (2003)

    Google Scholar 

  37. Oliveira, M.A.M., Boyer, C., Nele, M., Pinto, J.C., Zetterlund, P.B., Davis, T.P.: Macromolecules 44, 7167 (2011)

    Google Scholar 

  38. Jabbari, E., Nozari, S.: Iran. Polym. J. 8, 263 (1999)

    Google Scholar 

  39. Gehrke, S.H., Uhden, L.H., McBride, J.F.: J. Controlled Release 55, 21 (1998)

    Google Scholar 

  40. Coviello, T., Grassi, M., Rambone, G., Santucci, E., Carafa, M., Murtas, E., Riccieri, F.M., Alhaique, F.: J Control Release 60, 367 (1999)

    Google Scholar 

  41. Stevens, K.R., Einerson, N.J., Burmania, J.A., Kao, W.Y.J.: J. Biomater. Sci. Polym. Ed. 13, 1353 (2002)

    Google Scholar 

  42. Mirzaei, B.E., Ramazani, S.A.A., Shafiee, M., Danaei, M.: Int. J. Polym. Mater. Polym. Biomaterials 62, 605 (2013)

    Google Scholar 

  43. Wu, D.C., Loh, X.J., Wu, Y.L., Lay, C.L., Liu, Y.: J. Am. Chem. Soc. 132, 15140 (2010)

    Google Scholar 

  44. Cunanan, C.M., Graham, R.S., Manesis, N.J., Pettit, D.K., Deacon, J., Knight, P.M.: Surf. Modif. Polym. Biomaterials 129 (1997)

    Google Scholar 

  45. Ruiz, J., Mantecon, A., Cadiz, V.: Polymer 42, 6347 (2001)

    Google Scholar 

  46. Liu, Y., Vrana, N.E., Cahill, P.A., McGuinness, G.B.: J. Biomed. Mater. Res. B Appl. Biomater. 90B, 492 (2009)

    Google Scholar 

  47. Hennink, W.E., van Nostrum, C.F.: Adv. Drug Deliv. Rev. 54, 13 (2002)

    Google Scholar 

  48. Nge, T.T., Yamaguchi, M., Hori, N., Takemura, A., Ono, H.: J. Appl. Polym. Sci. 2002, 83 (1025)

    Google Scholar 

  49. de la Torre, P.M., Torrado, S., Torrado, S.: Biomaterials 24, 1459 (2003)

    Google Scholar 

  50. Decher, G., Hong, J.D., Schmitt, J.: Thin Solid Films 210, 831 (1992)

    Google Scholar 

  51. Decher, G.: Science 277, 1232 (1997)

    Google Scholar 

  52. Li, Z.Q., Guan, J.J.: Polymers 3, 740 (2011)

    Google Scholar 

  53. Shu, X.Z., Zhu, K.J.: Int. J. Pharm. 233, 217 (2002)

    Google Scholar 

  54. Ko, J.A., Park, H.J., Hwang, S.J., Park, J.B., Lee, J.S.: Int. J. Pharm. 249, 165 (2002)

    Google Scholar 

  55. Zhang, H.B., Zhang, F., Wu, J.: React. Funct. Polym. 73, 923 (2013)

    Google Scholar 

  56. Eagland, D., Crowther, N.J., Butler, C.J.: Eur. Polymer J. 30, 767 (1994)

    Google Scholar 

  57. Lowman, A.M., Peppas, N.A.: Macromolecules 30, 4959 (1997)

    Google Scholar 

  58. Kopecek, J., Yang, J.: Acta Biomater. 5, 805 (2009)

    Google Scholar 

  59. Kumar, P., Pillay, V., Modi, G., Choonara, Y.E., du Toit, L.C., Naidoo, D.: Recent Pat. Drug Deliv. Formul. 5, 24 (2011)

    Google Scholar 

  60. Rajagopal, K., Schneider, J.P.: Curr. Opin. Struct. Biol. 14, 480 (2004)

    Google Scholar 

  61. Wei, Y., Cui, F., Tian, W.: Front. Mater. Sci. China 3, 353 (2009)

    Google Scholar 

  62. Cui, Y., Li, Y.H., Duan, Q., Kakuchi, T.: Appl. Biochem. Biotechnol. 169, 239 (2013)

    Google Scholar 

  63. Ekici, S., Saraydin, D.: Polym. Int. 56, 1371 (2007)

    Google Scholar 

  64. Nishi, S., Kotaka, T.: Macromolecules 18, 1519 (1985)

    Google Scholar 

  65. Touhsaent, R.E., Thomas, D.A., Sperling, L.H.: J. Polym. Sci., Part C: Polym. Symp. 175 (1974)

    Google Scholar 

  66. Kim, I.Y., Yoo, M.K., Kim, B.C., Kim, S.K., Lee, H.C., Cho, C.S.: Int. J. Biol. Macromol. 38, 51 (2006)

    Google Scholar 

  67. Maurer, G., Prausnitz, J.M.: Fluid Phase Equilib. 115, 113 (1996)

    Google Scholar 

  68. Haynes, C.A., Benitez, F.J., Blanch, H.W., Prausnitz, J.M.: AIChE J. 39, 1539 (1993)

    Google Scholar 

  69. Haynes, C.A., Blanch, H.W., Prausnitz, J.M.: Fluid Phase Equilib. 53, 463 (1989)

    Google Scholar 

  70. Großmann, C., Maurer, G.: Fluid Phase Equilib. 106, 17 (1995)

    Google Scholar 

  71. King, R.S., Blanch, H.W., Prausnitz, J.M.: AIChE J. 34, 1585 (1988)

    Google Scholar 

  72. Wu, X.S., Hoffman, A.S., Yager, P.: J. Polym. Sci., Part A: Polym. Chem. 30, 2121 (1992)

    Google Scholar 

  73. Lutolf, M.P., Hubbell, J.A.: Biomacromolecules 4, 713 (2003)

    Google Scholar 

  74. Zhang, X.-Z., Wu, D.-Q., Chu, C.-C.: Biomaterials 25, 3793 (2004)

    Google Scholar 

  75. Stile, R.A., Burghardt, W.R., Healy, K.E.: Macromolecules 32, 7370 (1999)

    Google Scholar 

  76. Zhang, Y., Chu, C.-C.: J. Mater. Sci. Mater. Med. 13, 773 (2002)

    Google Scholar 

  77. Sayil, C., Okay, O.: Polymer 42, 7639 (2001)

    Google Scholar 

  78. Okay, O., Durmaz, S.: Polymer 43, 1215 (2002)

    Google Scholar 

  79. Fumio, U., Hiroshi, Y., Kumiko, N., Sachihiko, N., Kenji, S., Yasunori, M.: Int. J. Pharm. 58, 135 (1990)

    Google Scholar 

  80. Stavrouli, N., Aubry, T., Tsitsilianis, C.: Polymer 49, 1249 (2008)

    Google Scholar 

  81. Kim, S.H., Chu, C.C.: J. Biomed. Mater. Res. 53, 258 (2000)

    Google Scholar 

  82. Gemeinhart, R.A., Chen, J., Park, H., Park, K.: J. Biomater. Sci. Polym. Ed. 11, 1371 (2000)

    Google Scholar 

  83. Maia, J., Ferreira, L., Carvalho, R., Ramos, M.A., Gil, M.H.: Polymer 46, 9604 (2005)

    Google Scholar 

  84. Kuga, S.: J. Chromatogr. A 206, 449 (1981)

    Google Scholar 

  85. DePhillips, P., Lenhoff, A.M.: J. Chromatogr. A 883, 39 (2000)

    Google Scholar 

  86. Gonzales, D., Fan, K., Sevoian, M.: J. Polym. Sci., Part A: Polym. Chem. 1996, 34 (2019)

    Google Scholar 

  87. Shimokuri, T., Kaneko, T., Akashi, M.: J. Polym. Sci., Part A: Polym. Chem. 42, 4492 (2004)

    Google Scholar 

  88. Yao, B., Yang, C., Zhang, K., Ni, C., Song, H., Ni, Z., Chen, M.: Mater Sci Poland 27, 319 (2009)

    Google Scholar 

  89. Grimshaw, P.E., Nussbaum, J.H., Grodzinsky, A.J., Yarmush, M.L.: J. Chem. Phys. 93, 4462 (1990)

    Google Scholar 

  90. Kim, S.Y., Shin, H.S., Lee, Y.M., Jeong, C.N.: J. Appl. Polym. Sci. 73, 1675 (1999)

    Google Scholar 

  91. Segalman, D.J., Witkowski, W.R., Adolf, D.B., Shahinpoor, M.: Smart Mater. Struct. 1, 95 (1992)

    Google Scholar 

  92. Tanaka, T., Nishio, I., Sun, S.-T., Ueno-Nishio, S.: Science 218, 467 (1982)

    Google Scholar 

  93. Prudnikova, K., Utz, M.: Characterization of electromechanical transduction in polyelectrolyte gels for mechanical sensor applications. In MRS Proceedings, 1 edn., Cambridge University Press, p. 1006/

    Google Scholar 

  94. Shojaei, A.H.: J. Pharm. Pharm. Sci.: Publ Can Soc Pharm. Sci. (Societe canadienne des sciences pharmaceutiques) 1, 15 (1998)

    Google Scholar 

  95. Qiu, Y., Park, K.: Adv. Drug Deliv. Rev. 64, 49 (2012)

    Google Scholar 

  96. Win, P.P., Shin-ya, Y., Hong, K.J., Kajiuchi, T.: Carbohydr. Polym. 53, 305 (2003)

    Google Scholar 

  97. Chang, C.-H., Lin, Y.-H., Yeh, C.-L., Chen, Y.-C., Chiou, S.-F., Hsu, Y.-M., Chen, Y.-S., Wang, C.-C.: Biomacromolecules 11, 133 (2010)

    Google Scholar 

  98. Gisbert, J.P., Torrado, G., Torrado, S., Olivares, D., Pajares, J.M.: J. Clin. Gastroenterol. 40, 618 (2006)

    Google Scholar 

  99. Mladenovska, K., Raicki, R.S., Janevik, E.I., Ristoski, T., Pavlova, M.J., Kavrakovski, Z., Dodov, M.G., Goracinova, K.: Int. J. Pharm. 342, 124 (2007)

    Google Scholar 

  100. Wood, R.: Int. J. Pharm. 23, 175 (1985)

    Google Scholar 

  101. Cohen, S., Lobel, E., Trevgoda, A., Peled, Y.: J. Controlled Release 44, 201 (1997)

    Google Scholar 

  102. Cao, Y., Zhang, C., Shen, W., Cheng, Z., Yu, L., Ping, Q.: J. Controlled Release 120, 186 (2007)

    Google Scholar 

  103. Genta, I., Conti, B., Perugini, P., Pavanetto, F., Spadaro, A., Puglisi, G.: J. Pharm. Pharmacol. 49, 737 (1997)

    Google Scholar 

  104. El-Leithy, E.S., Shaker, D.S., Ghorab, M.K., Abdel-Rashid, R.S.: Aaps Pharmscitech 11, 1695 (2010)

    Google Scholar 

  105. Van Tomme, S.R., van Steenbergen, M.J., De Smedt, S.C., van Nostrum, C.F., Hennink, W.E.: Biomaterials 26, 2129 (2005)

    Google Scholar 

  106. Van Tomme, S.R., De Geest, B.G., Braeckmans, K., De Smedt, S.C., Siepmann, F., Siepmann, J., van Nostrum, C.F., Hennink, W.E.: J. Controlled Release 110, 67 (2005)

    Google Scholar 

  107. Li, S., Wang, X.-T., Zhang, X.-B., Yang, R.-J., Zhang, H.-Z., Zhu, L.-Z., Hou, X.-P.: J. Controlled Release 84, 87 (2002)

    Google Scholar 

  108. Du, J., Sun, R., Zhang, S., Zhang, L.-F., Xiong, C.-D., Peng, Y.-X.: Biopolymers 78, 1 (2005)

    Google Scholar 

  109. Du, J., Zhang, S., Sun, R., Zhang, L.F., Xiong, C.D., Peng, Y.X.: J. Biomed. Mater. Res. B Appl. Biomater. 72, 299 (2005)

    Google Scholar 

  110. Kim, S.J., Lee, K.J., Kim, S.I.: J. Appl. Polym. Sci. 2004, 93 (1097)

    Google Scholar 

  111. Shi, X., Du, Y., Sun, L., Zhang, B., Dou, A.: J. Appl. Polym. Sci. 100, 4614 (2006)

    Google Scholar 

  112. Lindhoud, S., de Vries, R., Schweins, R., Stuart Cohen, M.A., Norde, W.: Soft Matter 5, 242 (2009)

    Google Scholar 

  113. Johansson, C., Hansson, P., Malmsten, M.: J. Colloid Interface Sci. 316, 350 (2007)

    Google Scholar 

  114. Sarmento, B., Ribeiro, A.J., Veiga, F., Ferreira, D.C., Neufeld, R.J.: J. Nanosci. Nanotechnol. 7, 2833 (2007)

    Google Scholar 

  115. El-Sherbiny, I.M.: Carbohydr. Polym. 80, 1125 (2010)

    Google Scholar 

  116. Shu, S., Zhang, X., Teng, D., Wang, Z., Li, C.: Carbohydr. Res. 344, 1197 (2009)

    Google Scholar 

  117. Peppas, N.: Eur. J. Pharm. Biopharm. 50, 27 (2000)

    Google Scholar 

  118. Kim, J., Kim, I.S., Cho, T.H., Lee, K.B., Hwang, S.J., Tae, G., Noh, I., Lee, S.H., Park, Y., Sun, K.: Biomaterials 2007, 28 (1830)

    Google Scholar 

  119. Chang, T.M.S.: Science 146, 524 (1964)

    Google Scholar 

  120. Uludag, H., De Vos, P., Tresco, P.A.: Adv. Drug Deliv. Rev. 42, 29 (2000)

    Google Scholar 

  121. Lim, F., Sun, A.M.: Science 210, 908 (1980)

    Google Scholar 

  122. Hernandez, R.M., Orive, G., Murua, A., Pedraz, J.L.: Adv. Drug Deliv. Rev. 62, 711 (2010)

    Google Scholar 

  123. Hamano, T., Chiba, D., Nakatsuka, K., Nagahata, M., Teramoto, A., Kondo, Y., Hachimori, A., Abe, K.: Polym. Adv. Technol. 13, 46 (2002)

    Google Scholar 

  124. Denuziere, A., Ferrier, D., Damour, O., Domard, A.: Biomaterials 19, 1275 (1998)

    Google Scholar 

  125. Peniche, C., Fernández, M., Rodríguez, G., Parra, J., Jimenez, J., Bravo, A.L., Gómez, D., San Román, J.: J. Mater. Sci. Mater. Med. 18, 1719 (2007)

    Google Scholar 

  126. Mao, J.S., Cui, Y.L., Wang, X.H., Sun, Y., Yin, Y.J., Zhao, H.M., De Yao, K.: Biomaterials 25, 3973 (2004)

    Google Scholar 

  127. Xia, W., Liu, W., Cui, L., Liu, Y., Zhong, W., Liu, D., Wu, J., Chua, K., Cao, Y.: J. Biomed. Mater. Res. 71B, 373 (2004)

    Google Scholar 

  128. Guo, T., Zhao, J., Chang, J., Ding, Z., Hong, H., Chen, J., Zhang, J.: Biomaterials 2006, 27 (1095)

    Google Scholar 

  129. Yan, X.-L., Khor, E., Lim, L.-Y.: J. Biomed. Mater. Res. 58, 358 (2001)

    Google Scholar 

  130. Nettles, D.L., Elder, S.H., Gilbert, J.A.: Tissue Eng. 2002, 8 (1009)

    Google Scholar 

  131. Li, Z., Zhang, M.: J. Biomed. Mater. Res. Part A 75A, 485 (2005)

    Google Scholar 

  132. Kratz, G., Arnander, C., Swedenborg, J., Back, M., Falk, C., Gouda, I., Larm, O.: Scand. J. Plast. Reconstr. Surg. Hand Surg. 31, 119 (1997)

    Google Scholar 

  133. Wang, X.H., Yan, Y.N., Lin, F., Xiong, Z., Wu, R.D., Zhang, R.J., Lu, Q.P.: J. Biomater. Sci. Polym. Ed. 2005, 16 (1063)

    Google Scholar 

  134. Seo, S.J., Choi, Y.J., Akaike, T., Higuchi, A., Cho, C.S.: Tissue Eng. 12, 33 (2006)

    Google Scholar 

  135. Villalonga, R., Fernández, M., Fragoso, A., Cao, R., Mariniello, L., Porta, R.: Biotechnol. Appl. Biochem. 38, 53 (2003)

    Google Scholar 

  136. Gómez, L., Ramírez, H.L., Neira-Carrillo, A., Villalonga, R.: Bioprocess Biosyst. Eng. 28, 387 (2006)

    Google Scholar 

  137. Liu, Y., Lu, H., Zhong, W., Song, P., Kong, J., Yang, P., Girault, H.H., Liu, B.: Anal. Chem. 78, 801 (2006)

    Google Scholar 

  138. Constantine, C.A., Mello, S.V., Dupont, A., Cao, X., Santos, D., Oliveira, O.N., Strixino, F.T., Pereira, E.C., Cheng, T.-C., Defrank, J.J., Leblanc, R.M.: J. Am. Chem. Soc. 2003, 125 (1805)

    Google Scholar 

  139. Elnashar, M.M.M., Yassin, M.A.: Appl. Biochem. Biotechnol. 159, 426 (2008)

    Google Scholar 

  140. Aranaz, I., Acosta, N., Heras, A.: J. Mol. Catal. B Enzym. 58, 54 (2009)

    Google Scholar 

  141. Taqieddin, E., Amiji, M.: Biomaterials 2004, 25 (1937)

    Google Scholar 

  142. Sankalia, M.G., Mashru, R.C., Sankalia, J.M., Sutariya, V.B.: Eur. J. Pharm. Biopharm. 65, 215 (2007)

    Google Scholar 

  143. Yapar, E., Kayahan, S.K., Bozkurt, A., Toppare, L.: Carbohydr. Polym. 76, 430 (2009)

    Google Scholar 

  144. Izumrudov, V.A., Galaev, I., Mattiasson, B.: Bioseparation 7, 207 (1998)

    Google Scholar 

  145. Kayitmazerb, Basak: D.S.A., Minskya, B.B., Dubina, P.L., Xu, Y. Soft Matter 9, 2553 (2013)

    Google Scholar 

  146. de Vasconcelos, C.L., Bezerril, P.M., Dantas, T.N.C., Pereira, M.R., Fonseca, J.L.C.: Langmuir 23, 7687 (2007)

    Google Scholar 

  147. Hartig, S.M., Carlesso, G., Davidson, J.M., Prokop, A.: Biomacromolecules 8, 265 (2007)

    Google Scholar 

  148. Dissing, U., Mattiasson, B.: J. Biotechnol. 52, 1 (1996)

    Google Scholar 

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Authors and Affiliations

  1. The Translational Tissue Engineering Center, The Johns Hopkins University, Baltimore, MD, USA

    Xue-Song Jiang, Mohit Philip Mathew & Jian Du

  2. Department of Materials Science and Engineering, The Johns Hopkins University, Baltimore, MD, USA

    Xue-Song Jiang

  3. Department of Biomedical Engineering, The Johns Hopkins University, Baltimore, MD, USA

    Mohit Philip Mathew & Jian Du

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  1. Xue-Song Jiang
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  2. Mohit Philip Mathew
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  3. Jian Du
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Correspondence to Jian Du .

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Editors and Affiliations

  1. School of Chemical Sciences, Mahatma Gandhi University, Kottayam, Kerala, India

    Visakh P. M.

  2. Izmir Institute of Technology, Department of Chemical Engineering, Gülbahçe, Urla, Izmir, Turkey

    Oguz Bayraktar

  3. Biotechnological Process Laboratory, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Rosario, Argentina

    Guillermo Alfredo Picó

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Jiang, XS., Mathew, M.P., Du, J. (2014). Polyelectrolyte Hydrogels: Thermodynamics. In: P. M., V., Bayraktar, O., Picó, G. (eds) Polyelectrolytes. Engineering Materials. Springer, Cham. https://doi.org/10.1007/978-3-319-01680-1_5

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