The Neurobiology of Meditation and Mindfulness

  • Tobias EschEmail author
Part of the Studies in Neuroscience, Consciousness and Spirituality book series (SNCS, volume 2)


Neurobiological effects of meditation and mindfulness can be detected in the brain as functional and also structural alterations in grey and white matter, particularly in areas related to attention and memory, interoception and sensory processing, or self- and auto-regulation (including control of stress and emotions). On the molecular level, dopamine and melatonin are found to increase, serotonin activity is modulated, and cortisol as well as norepinephrine have been proven to decrease. These findings are reflected in functional and structural changes documented by imaging techniques such as fMRI or EEG. They may be relevant for medicine and health care, especially with reference to therapeutic strategies for behavior change and life-style modification, or in association with stress regulation and the treatment of addiction. Neuronal mechanisms of mindfulness can be divided into four areas: attention regulation, body awareness, emotion regulation and self-perception.


Anterior Cingulated Cortex Default Mode Network Mirror Neuron Mindfulness Training Mindfulness Meditation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Anterior cingulated cortex


Brain-derived neurotrophic factor






Functional magnetic resonance imaging




Posterior cingulated cortex


Prefrontal cortex


  1. Aftanas, L.I., and S.A. Golocheikine. 2001. Human anterior and frontal midline theta and lower alpha reflect emotionally positive state and internalized attention: High-resolution EEG investigation of meditation. Neuroscience Letters 310: 57–60.PubMedGoogle Scholar
  2. Aftanas, L.I., and S.A. Golocheikine. 2002. Non-linear dynamic complexity of the human EEG during meditation. Neuroscience Letters 330: 143–146.PubMedGoogle Scholar
  3. Baijal, S., and N. Srinivasan. 2010. Theta activity and meditative states: Spectral changes during concentrative meditation. Cognitive Processing 11: 31–38.PubMedGoogle Scholar
  4. Benson, H., and M.Z. Klipper. 2000. The relaxation response. New York: Harper Collins.Google Scholar
  5. Bisaz, R., and R.M. Sullivan. 2012. Developmental neurobiology of the rat attachment systems and its modulation by stress. Behavioral Sciences 2: 79–102.PubMedCentralPubMedGoogle Scholar
  6. Bishop, S.R., M. Lau, S. Shapiro, L. Carlson, N.D. Anderson, J. Carmody, et al. 2004. Mindfulness. A proposed operational definition. Clinical Psychology: Science and Practice 11(3): 230–241.Google Scholar
  7. Brand, S., E. Holsboer-Trachsler, J.R. Naranjo, and S. Schmidt. 2012. Influence of mindfulness practice on cortisol and sleep in long-term and short-term meditators. Neuropsychobiology 65: 109–118.PubMedGoogle Scholar
  8. Brefczynski-Lewis, J.A., A. Lutz, H.S. Schaefer, D.B. Levinson, and R.J. Davidson. 2007. Neural correlates of attentional expertise in long-term meditation practitioners. Proceedings of the National Academy of Sciences of the United States of America 104: 11483–11488.PubMedCentralPubMedGoogle Scholar
  9. Bujatti, M., and P. Riederer. 1976. Serotonin, noradrenaline, dopamine metabolites in transcendental meditation-technique. Journal of Neural Transmission 39: 257–267.PubMedGoogle Scholar
  10. Cahn, B.R., A. Delorme, and J. Polich. 2010. Occipital gamma activation during Vipassana meditation. Cognitive Processing 11: 39–56.PubMedCentralPubMedGoogle Scholar
  11. Cahn, B.R., A. Delorme, and J. Polich. 2012. Event-related delta, theta, alpha, and gamma correlates to auditory oddball processing during Vipassana meditation. Social Cognitive and Affective Neuroscience 8: 100–111.PubMedCentralPubMedGoogle Scholar
  12. Creswell, J.D., B.M. Way, N.I. Eisenberger, and M.D. Lieberman. 2007. Neural correlates of dispositional mindfulness during affect labeling. Psychosomatic Medicine 69: 560–565.PubMedGoogle Scholar
  13. Critchley, H.D., R.N. Melmed, E. Featherstone, C.J. Mathias, and R.J. Dolan. 2001. Brain activity during biofeedback relaxation: A functional neuroimaging investigation. Brain 124: 1003–1012.PubMedGoogle Scholar
  14. Davidson, R.J. 1998. Anterior electrophysiological asymmetries, emotion, and depression: Conceptual and methodological conundrums. Psychophysiology 35: 607–614.PubMedGoogle Scholar
  15. Davidson, R.J., J. Kabat-Zinn, J. Schumacher, M. Rosenkranz, D. Muller, S.F. Santorelli, et al. 2003. Alterations in brain and immune function produced by mindfulness meditation. Psychosomatic Medicine 65: 564–570.PubMedGoogle Scholar
  16. Desbordes, G., L.T. Negi, T.W.W. Pace, B.A. Wallace, C.L. Raison, and E.L. Schwartz. 2012. Effects of mindful-attention and compassion meditation training on amygdala response to emotional stimuli in an ordinary, non-meditative state. Frontiers in Human Neuroscience 6: 292.PubMedCentralPubMedGoogle Scholar
  17. Dusek, J.A., B.H. Chang, J. Zaki, S. Lazar, A. Deykin, G.B. Stefano, et al. 2006. Association between oxygen consumption and nitric oxide production during the relaxation response. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 12: CR1–CR10.Google Scholar
  18. Dusek, J.A., H.H. Otu, A.L. Wohlhueter, M. Bhasin, L.F. Zerbini, M.G. Joseph, et al. 2008. Genomic counter-stress changes induced by the relaxation response. PLoS One 3: e2576.PubMedCentralPubMedGoogle Scholar
  19. Ernst, S., J. Welke, C. Heintze, R. Gabriel, A. Zöllner, S. Kiehne, et al. 2008. Effects of mindfulness-based stress reduction on quality of life in nursing home residents: A feasibility study. Forschende Komplementärmedizin 15: 74–81.PubMedGoogle Scholar
  20. Ernst, S., S.M. Esch, and T. Esch. 2009. Die Bedeutung achtsamkeitbasierter Interventionen in der medizinischen und psychotherapeutischen Versorgung [The impact of mindfulness-based interventions on health care]. Forschende Komplementärmedizin 16: 296–303.PubMedGoogle Scholar
  21. Esch, T. 2002. Gesund im Stress: Der Wandel des Stresskonzeptes und seine Bedeutung für Prävention, Gesundheit und Lebensstil [Health in stress: Change in the stress concept and its significance for prevention, health and life style]. Gesundheitswesen 64: 73–81.PubMedGoogle Scholar
  22. Esch, T. 2003. Stress, Anpassung und Selbstorganisation: Gleichgewichtsprozesse sichern Gesundheit und Überleben [Stress, adaptation, and self-organization: Balancing processes facilitate health and survival]. Forschende Komplementärmedizin 10: 330–341.PubMedGoogle Scholar
  23. Esch, T. 2008. Mind-body-Medizin: Stress, Stressmanagement und Gesundheitsförderung [Mind-body medicine: Stress, stress management and health promotion]. Komplementäre und Integrative Medizin 49: 35–39.Google Scholar
  24. Esch, T. 2010. Von der Kuration zur Gesundheitsförderung: Paradigmenwechsel in der ärztlichen Beratung. In Adipositas und Public Health. Rahmenbedingungen, interdisziplinäre Zugänge und Perspektiven für erfolgreiche Präventionsstrategien, ed. C. Heintze. München: Juventa.Google Scholar
  25. Esch, T. 2011. Die Neurobiologie des Glücks. Wie die Positive Psychologie die Medizin verändert. Stuttgart: Thieme.Google Scholar
  26. Esch, T., and S.M. Esch. 2013. Stressbewältigung mithilfe der Mind-Body-Medizin: Trainingsmanual zur Integrativen Gesundheitsförderung. Berlin: MWV.Google Scholar
  27. Esch, T., and G.B. Stefano. 2004. The neurobiology of pleasure, reward processes, addiction and their health implications. Neuroendocrinology Letters 25: 235–251.PubMedGoogle Scholar
  28. Esch, T., and G.B. Stefano. 2005. The neurobiology of love. Neuroendocrinology Letters 26: 175–192.PubMedGoogle Scholar
  29. Esch, T., and G.B. Stefano. 2010. The neurobiology of stress management. Neuroendocrinology Letters 31: 19–39.PubMedGoogle Scholar
  30. Esch, T., and G.B. Stefano. 2011. The neurobiological link between compassion and love. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 17: RA65–RA75.Google Scholar
  31. Esch, T., G.B. Stefano, G.L. Fricchione, and H. Benson. 2002. An overview of stress and its impact in immunological diseases. Modern Aspects of Immunobiology 2: 187–192.Google Scholar
  32. Esch, T., G.B. Stefano, and G.L. Fricchione. 2003. The therapeutic use of the relaxation response in stress-related diseases. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 9: RA23–RA34.Google Scholar
  33. Esch, T., M. Guarna, E. Bianchi, and G.B. Stefano. 2004a. Meditation and limbic processes. Biofeedback 32: 22–32.Google Scholar
  34. Esch, T., M. Guarna, E. Bianchi, W. Zhu, and G.B. Stefano. 2004b. Commonalities in the central nervous system’s involvement with complementary medical therapies: Limbic morphinergic processes. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 10: MS6–MS17.Google Scholar
  35. Esch, T., J. Duckstein, J. Welke, and V. Braun. 2007. Mind/body techniques for physiological and psychological stress reduction: Stress management via Tai Chi training – a pilot study. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 13: CR488–CR497.Google Scholar
  36. Esch, T., U. Sonntag, S.M. Esch, and S. Thees. 2013. Stress management and mind-body medicine: A randomized controlled longitudinal evaluation of students’ health and effects of a behavioral group intervention at a middle-size German University (SM-MESH). Forschende Komplementärmedizin 20: 129–137. doi: 10.1016/j.ctcp.2009.01.003.PubMedGoogle Scholar
  37. Evron, T., L.B. Moyal-Segal, N. Lamm, A. Geffen, and H. Soreq. 2005. RNA-targeted suppression of stress-induced allostasis in primate spinal cord neurons. Neurodegenerative Diseases 2: 16–27.PubMedGoogle Scholar
  38. Farb, N.A.S., Z.V. Segal, H. Mayberg, J. Bean, D. McKeon, Z. Fatima, et al. 2007. Attending to the present: Mindfulness meditation reveals distinct neural modes of self-reference. Social Cognitive and Affective Neuroscience 2: 313–322.PubMedCentralPubMedGoogle Scholar
  39. Fjorback, L.O., M. Arendt, E. Ornbøl, P. Fink, and H. Walach. 2011. Mindfulness-based stress reduction and mindfulness-based cognitive therapy: A systematic review of randomized controlled trials. Acta Psychiatrica Scandinavica 124: 102–119.PubMedGoogle Scholar
  40. Gard, T., B.K. Hölzel, A.T. Sack, H. Hempel, S.W. Lazar, D. Vaitl, et al. 2012. Pain attenuation through mindfulness is associated with decreased cognitive control and increased sensory processing in the brain. Cerebral Cortex 22: 2692–2702.PubMedCentralPubMedGoogle Scholar
  41. Groppe, S.E., A. Gossen, L. Rademacher, A. Hahn, L. Westphal, G. Gründer, et al. 2013. Oxytocin influences processing of socially relevant cues in the ventral tegmental area of the human brain. Biological Psychiatry 74(3): 172–179. pii: S0006-3223(13)00039-5.PubMedGoogle Scholar
  42. Grossman, P., L. Niemann, S. Schmidt, and H. Walach. 2004. Mindfulness-based stress reduction and health benefits. A meta-analysis. Journal of Psychosomatic Research 57: 35–43.PubMedGoogle Scholar
  43. Hanson, R. 2009. Buddha’s brain. The practical neuroscience of happiness, love and wisdom. Oakland: New Harbinger.Google Scholar
  44. Hinterberger, T., T. Kamei, and H. Walach. 2011. Psychophysiological classification and staging of mental states during meditative practice. Biomedizinische Technik/Biomedical engineering 56: 341–350.Google Scholar
  45. Hoffman, J.W., H. Benson, P.A. Arns, G.L. Stainbrook, G.L. Landsberg, J.B. Young, et al. 1982. Reduced sympathetic nervous system responsivity associated with the relaxation response. Science 215: 190–192.PubMedGoogle Scholar
  46. Hölzel, B.K., U. Ott, H. Hempel, A. Hackl, K. Wolf, R. Stark, et al. 2007. Differential engagement of anterior cingulate and adjacent medial frontal cortex in adept meditators and non-meditators. Neuroscience Letters 421: 16–21.PubMedGoogle Scholar
  47. Hölzel, B.K., U. Ott, T. Gard, H. Hempel, M. Weygandt, K. Morgen, et al. 2008. Investigation of mindfulness meditation practitioners with voxel-based morphometry. Social Cognitive and Affective Neuroscience 3: 55–61.PubMedCentralPubMedGoogle Scholar
  48. Hölzel, B.K., J. Carmody, K.C. Evans, E.A. Hoge, J.A. Dusek, L. Morgan, et al. 2010. Stress reduction correlates with structural changes in the amygdala. Social Cognitive and Affective Neuroscience 5: 11–17.PubMedCentralPubMedGoogle Scholar
  49. Hölzel, B.K., J. Carmody, M. Vangel, C. Congleton, S.M. Yerramsetti, T. Gard, et al. 2011a. Mindfulness practice leads to increases in regional brain gray matter density. Psychiatry Research 191: 36–43.PubMedCentralPubMedGoogle Scholar
  50. Hölzel, B.K., S.W. Lazar, T. Gard, Z. Schuman-Olivier, D.R. Vago, and U. Ott. 2011b. How does mindfulness meditation work? Proposing mechanisms of action from a conceptual and neural perspective. Perspectives on Psychological Science 6: 537–559.Google Scholar
  51. Infante, J.R., M. Torres-Avisbal, P. Pinel, J.A. Vallejo, F. Peran, F. Gonzalez, et al. 2001. Catecholamine levels in practitioners of the transcendental meditation technique. Physiology and Behavior 72: 141–146.PubMedGoogle Scholar
  52. Jacobs, G.D., H. Benson, and R. Friedman. 1996. Topographic EEG mapping of the relaxation response. Biofeedback and Self Regulation 21: 121–129.PubMedGoogle Scholar
  53. Jung, Y.H., D.H. Kang, J.H. Jang, H.Y. Park, M.S. Byun, S.J. Kwon, et al. 2010. The effects of mind-body training on stress reduction, positive affect, and plasma catecholamines. Neuroscience Letters 479: 138–142.PubMedGoogle Scholar
  54. Jung, Y.H., D.H. Kang, M.S. Byun, G. Shim, S.J. Kwon, G.E. Jang, et al. 2012. Influence of brain-derived neurotrophic factor and catechol O-methyl transferase polymorphisms on effects of meditation on plasma catecholamines and stress. Stress 15: 97–104.PubMedGoogle Scholar
  55. Kabat-Zinn, J. 1990. Full catastrophe living: Using the wisdom of your body and mind to face stress, pain, and illness. New York: Delta.Google Scholar
  56. Kang, D.H., H.J. Jo, W.H. Jung, S.H. Kim, Y.H. Jung, C.H. Choi, et al. 2013. The effect of meditation on brain structure: cortical thickness mapping and diffusion tensor imaging. Social Cognitive and Affective Neuroscience 8: 27–33.PubMedCentralPubMedGoogle Scholar
  57. Kerr, C.E., S.R. Jones, Q. Wan, D.L. Pritchett, R.H. Wasserman, A. Wexler, et al. 2011. Effects of mindfulness meditation training on anticipatory alpha modulation in primary somatosensory cortex. Brain Research Bulletin 85: 96–103.PubMedGoogle Scholar
  58. Khalsa, D.S., D. Amen, C. Hanks, N. Money, and A. Newberg. 2009. Cerebral blood flow changes during chanting meditation. Nuclear Medicine Communications 30: 956–961.PubMedGoogle Scholar
  59. Kjaer, T.W., C. Bertelsen, P. Piccini, D. Brooks, J. Alving, and H.C. Lou. 2002. Increased dopamine tone during meditation-induced change of consciousness. Brain Research. Cognitive Brain Research 13: 255–259.PubMedGoogle Scholar
  60. Kubota, Y., W. Sato, M. Toichi, T. Murai, T. Okada, A. Hayashi, et al. 2001. Frontal midline theta rhythm is correlated with cardiac autonomic activities during the performance of an attention demanding meditation procedure. Research. Cognitive Brain Research 11: 281–287.Google Scholar
  61. Lagopoulos, J., J. Xu, I. Rasmussen, A. Vik, G.S. Malhi, C.F. Eliassen, et al. 2009. Increased theta and alpha EEG activity during nondirective meditation. Journal of Alternative and Complementary Medicine 15: 1187–1192.Google Scholar
  62. Lazar, S.W. 2011. The meditating brain. Berlin: 4. Europäischer Kongress für Integrative Medizin.Google Scholar
  63. Lazar, S.W., G. Bush, R.L. Gollub, G.L. Fricchione, G. Khalsa, and H. Benson. 2000. Functional brain mapping of the relaxation response and meditation. Neuroreport 11: 1581–1585.PubMedGoogle Scholar
  64. Lazar, S.W., C.E. Kerr, R.H. Wasserman, J.R. Gray, D.N. Greve, M.T. Treadway, et al. 2005. Meditation experience is associated with increased cortical thickness. Neuroreport 16: 1893–1897.PubMedCentralPubMedGoogle Scholar
  65. Linden, W. 2000. Meditation. In Handbuch der Entspannungsverfahren, Band 1: Grundlagen und Methoden, ed. D. Vaitl and F. Petermann, 256–268. Weinheim: Psychologie Verlags Union.Google Scholar
  66. Liou, C.H., C.W. Hsieh, C.H. Hsieh, D.Y. Chen, C.H. Wang, J.H. Chen, et al. 2010. Detection of nighttime melatonin level in Chinese Original Quiet Sitting. Journal of the Formosan Medical Association 109: 694–701.PubMedGoogle Scholar
  67. Luders, E., K. Clark, K.L. Narr, and A.W. Toga. 2011. Enhanced brain connectivity in long-term meditation practitioners. Neuroimage 57: 1308–1316.PubMedCentralPubMedGoogle Scholar
  68. Lustyk, M.K., N. Chawla, R.S. Nolan, and G.A. Marlatt. 2009. Mindfulness meditation research: Issues of participant screening, safety procedures, and researcher training. Advances in Mind Body Medicine 24: 20–30.PubMedGoogle Scholar
  69. Lutz, A., L.L. Greischar, N.B. Rawlings, M. Ricard, and R.J. Davidson. 2004. Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the National Academy of Sciences of the United States of America 101: 16369–16373.PubMedCentralPubMedGoogle Scholar
  70. Malinowski, P. 2012. Wirkmechanismen der Achtsamkeitspraxis. Wie fördert Meditation positive psychologische Veränderungen? In Achtsamkeit: Ein buddhistisches Konzept erobert die Wissenschaft, ed. M. Zimmermann, C. Spitz, and S. Schmidt, 91–100. Bern: Hans Huber.Google Scholar
  71. Manoch, R., A. Gordon, D. Black, G. Malhi, and R. Seidler. 2009. Using meditation for less stress and better wellbeing: A seminar for GPs. Australian Family Physician 38: 454–458.PubMedGoogle Scholar
  72. Mantione, K.J., T. Esch, and G.B. Stefano. 2007. Detection of nitric oxide in exhaled human breath: Exercise and resting determinations. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 13: MT1–MT5.Google Scholar
  73. Mantione, K.J., P. Cadet, W. Zhu, R.M. Kream, M. Sheehan, G.L. Fricchione, et al. 2008. Endogenous morphine signaling via nitric oxide regulates the expression of CYP2D6 and COMT: Autocrine/paracrine feedback inhibition. Addiction Biology 13: 118–123.PubMedGoogle Scholar
  74. Mantione, K.J., W. Zhu, R.M. Kream, T. Esch, and G. Stefano. 2010a. Regulation of the transcription of the catechol-O-methyltransferase gene by morphine and epinephrine. Activitas Nervosa Superior Rediviva 52: 51–56.Google Scholar
  75. Mantione, K.J., R.M. Kream, and G.B. Stefano. 2010b. Variations in critical morphine biosynthesis genes and their potential to influence human health. Neuroendocrinology Letters 31: 11–18.PubMedGoogle Scholar
  76. Marchand, W.R. 2012. Mindfulness-based stress reduction, mindfulness-based cognitive therapy, and zen meditation for depression, anxiety, pain, and psychological distress. Journal of Psychiatric Practice 18: 233–252.PubMedGoogle Scholar
  77. McAvoy, M., L. Larson-Prior, T.S. Nolan, S.N. Vaishnavi, M.E. Raichle, and G. d’Avossa. 2008. Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortex. Journal of Neurophysiology 100: 922–931.PubMedCentralPubMedGoogle Scholar
  78. McColl, C., and T. Singer. 2012. The animal and human neuroendocrinology of social cognition, motivation and behavior. Nature Neuroscience 15: 681–688.Google Scholar
  79. Mendelson, T., M.T. Greenberg, J.K. Dariotis, L.F. Gould, B.L. Rhoades, and P.J. Leaf. 2010. Feasibility and preliminary outcomes of a school-based mindfulness intervention for urban youth. Journal of Abnormal Child Psychology 38: 985–994.PubMedGoogle Scholar
  80. Mohan, A., R. Sharma, and R.L. Bijlani. 2011. Effect of meditation on stress-induced changes in cognitive functions. Journal of Alternative and Complementary Medicine 17: 207–212.Google Scholar
  81. Newberg, A.B., and J. Iversen. 2003. The neural basis of the complex mental task of meditation: neurotransmitter and neurochemical considerations. Medical Hypotheses 61: 282–291.PubMedGoogle Scholar
  82. Newberg, A., A. Alavi, M. Baime, M. Pourdehnad, J. Santanna, and E. d’Aquili. 2001. The measurement of regional cerebral blood flow during the complex cognitive task of meditation: A preliminary SPECT study. Psychiatry Research 106: 113–122.PubMedGoogle Scholar
  83. Newberg, A.B., N. Wintering, M.R. Waldman, D. Amen, D.S. Khalsa, and A. Alavi. 2010. Cerebral blood flow differences between long-term meditators and non-meditators. Consciousness and Cognition 19: 899–905.PubMedGoogle Scholar
  84. Ott, U. 2010. Meditation für Skeptiker. München: O.W. Barth.Google Scholar
  85. Pagnoni, G., and M. Cekic. 2007. Age effects on gray matter volume and attentional performance in Zen meditation. Neurobiology of Aging 28: 1623–1627.PubMedGoogle Scholar
  86. Pagnoni, G., M. Cekic, and Y. Guo. 2008. “Thinking about not-thinking”: Neural correlates of conceptual processing during Zen meditation. PLOS One 3(9): e3083.PubMedCentralPubMedGoogle Scholar
  87. Petermann, F., and D. Vaitl. 2009. Entspannungsverfahren: Das Praxishandbuch. Beltz: Weinheim.Google Scholar
  88. Pizoli, C.E., M.N. Shah, A.Z. Snyder, J.S. Shimony, D.D. Limbrick, M.E. Raichle, et al. 2011. Resting-state activity in development and maintenance of normal brain function. Proceedings of the National Academy of Sciences of the United States of America 108: 11638–11643.PubMedCentralPubMedGoogle Scholar
  89. Plews-Ogan, M., J.E. Owens, M. Goodman, P. Wolfe, and J. Schorling. 2005. Brief report: A pilot study evaluating mindfulness-based stress reduction and massage for the management of chronic pain. Journal of General Internal Medicine 20: 1136–1138.PubMedCentralPubMedGoogle Scholar
  90. Rosengren, A., S. Hawken, S. Ounpuu, K. Sliwa, M. Zubaid, W.A. Almahmeed, et al. 2004. INTERHEART investigators. Association of psychosocial risk factors with risk of acute myocardial infarction in 11119 cases and 13648 controls from 52 countries (the INTERHEART study): Case–control study. Lancet 364: 953–962.PubMedGoogle Scholar
  91. Rossano, M. 2007. Did meditating make us human? Cambridge Archaeological Journal 17(1): 47–58.Google Scholar
  92. Russ, T.C., E. Stamatakis, M. Hamer, J.M. Starr, M. Kivimäki, and G.D. Batty. 2012. Association between psychological distress and mortality: Individual participant pooled analysis of 10 prospective cohort studies. British Medical Journal 345: E4933. doi: 10.1136/bmj.e4933.PubMedCentralPubMedGoogle Scholar
  93. Salzberg, S., and J. Kabat-Zinn. 2000. Achtsamkeit als Medikament. In Die heilende Kraft der Gefühle, ed. D. Goleman, 134–181. München: Dt. Taschenbuch-Verl.Google Scholar
  94. Sauer, S., H. Walach, and N. Kohls. 2011. Gray’s behavioural inhibition system as a mediator of mindfulness towards well-being. Personality and Individual Differences 50: 506–511.Google Scholar
  95. Schmidt, S., P. Grossman, B. Schwarzer, S. Jena, J. Naumann, and H. Walach. 2011. Treating fibromyalgia with mindfulness-based stress reduction: Results from a 3-armed randomized controlled trial. Pain 152: 361–369.PubMedGoogle Scholar
  96. Schnabel, U. 2010. Muße – Vom Glück des Nichtstuns. München: Blessing.Google Scholar
  97. Siegel, D.J. 2007. The mindful brain. New York: Norton.Google Scholar
  98. Singer, T. 2010. Motivational systems in the brain. Mind & Life XX conference: altruism and compassion in economic systems. Session: Altruism: Evolutionary origins and modern expressions. Host: Mind & Life International, Co-Sponsored by The Mind & Life Institute and The University of Zürich, Kongresshaus, Zürich, 9 April.Google Scholar
  99. Solberg, E.E., A. Holen, Ø. Ekeberg, B. Østerud, R. Halvorsen, and L. Sandvik. 2004. The effects of long meditation on plasma melatonin and blood serotonin. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 10: CR96–CR101.Google Scholar
  100. Sonntag, U., T. Esch, L. von Hagen, B. Renneberg, V. Braun, and C. Heintze. 2010. Locus of control, self-efficacy and attribution tendencies in obese patients – implications for primary care consultations. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 16: CR330–CR335.Google Scholar
  101. Stefano, G.B., and T. Esch. 2005. Integrative medical therapy: Examination of meditation’s therapeutic and global medicinal outcomes via nitric oxide. International Journal of Molecular Medicine 16: 621–630.PubMedGoogle Scholar
  102. Stefano, G.B., H. Benson, G.L. Fricchione, and T. Esch. 2005. The stress response: Always good and when it is bad. New York: Medical Science International.Google Scholar
  103. Stefano, G.B., G.L. Fricchione, and T. Esch. 2006. Relaxation: Molecular and physiological significance. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 12: HY21–HY31.Google Scholar
  104. Teasdale, J.D., Z.V. Segal, and J.M. Williams. 1995. How does cognitive therapy prevent depressive relapse and why should attentional control (mindfulness training) help? Behaviour Research and Therapy 33: 25–39.PubMedGoogle Scholar
  105. Teasdale, J.D., R.G. Moore, H. Hayhurst, M. Pope, S. Williams, and Z.V. Segal. 2002. Metacognitive awareness and prevention of relapse in depression: Empirical evidence. Journal of Consulting and Clinical Psychology 70: 275–287.PubMedGoogle Scholar
  106. Thees, S., J. Gobel, G. Jose, R. Bohrhardt, and T. Esch. 2012. Die Gesundheit von Studierenden im Bologna-Prozess: Untersuchungen zu Gesundheitsverhalten, Stress und Wohlbefinden zeigen Handlungsbedarf. Prävention und Gesundheitsförderung 3: 196–202.Google Scholar
  107. van Leeuwen, S., N.G. Müller, and L. Melloni. 2009. Age effects on attentional blink performance in meditation. Consciousness and Cognition 18: 593–599.PubMedGoogle Scholar
  108. Vestergaard-Poulsen, P., M. van Beek, J. Skewes, C.R. Bjarkam, M. Stubberup, J. Bertelsen, et al. 2009. Long-term meditation is associated with increased gray matter density in the brain stem. Neuroreport 20: 170–174.PubMedGoogle Scholar
  109. Vøllestad, J., M.B. Nielsen, and G.H. Nielsen. 2012. Mindfulness- and acceptance-based interventions for anxiety disorders: A systematic review and meta-analysis. British Journal of Clinical Psychology 51: 239–260.PubMedGoogle Scholar
  110. Walach, H. 2010. Wie Achtsamkeit und Meditation unsere Arbeitskultur verändern können. Berlin: Meditation und Wissenschaft.Google Scholar
  111. Walach, H., E. Nord, C. Zier, B. Dietz-Waschkowski, S. Kersig, and H. Schϋpbach. 2007. Mindfulness-based stress reduction as a method for personnel development: A pilot evaluation. International Journal of Stress Management 14: 188–198.Google Scholar
  112. Walton, K.G., N.D. Pugh, P. Gelderloos, and P. Macrae. 1995. Stress reduction and preventing hypertension: preliminary support for a psychoneuroendocrine mechanism. Journal of Alternative and Complementary Medicine 1: 263–283.Google Scholar
  113. Wang, D.J., H. Rao, M. Korczykowski, N. Wintering, J. Pluta, D.S. Khalsa, et al. 2011. Cerebral blood flow changes associated with different meditation practices and perceived depth of meditation. Psychiatry Research 191: 60–67.PubMedGoogle Scholar
  114. Williams, J.M., J.D. Teasdale, Z.V. Segal, and J. Soulsby. 2000. Mindfulness- based cognitive therapy reduces overgeneral autobiographical memory in formerly depressed patients. Journal of Abnormal Psychology 109: 150–155.PubMedGoogle Scholar
  115. Yu, X., M. Fumoto, Y. Nakatani, T. Sekiyama, H. Kikuchi, Y. Seki, et al. 2011. Activation of the anterior prefrontal cortex and serotonergic system is associated with improvements in mood and EEG changes induced by Zen meditation practices in novices. International Journal of Psychophysiology 80: 103–111.PubMedGoogle Scholar
  116. Zeidan, F., S.K. Johnson, and B.J. Diamond. 2010. Mindfulness meditation improves cognition: evidence of brief mental training. Consciousness and Cognition 19: 597–605.PubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Division of Integrative Health PromotionHealthy University, Coburg University of Applied SciencesCoburgGermany
  2. 2.Neuroscience Research InstituteState University of New YorkNew YorkUSA

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