Adverse Effects of Bisphenol A on Male Reproductive Function

  • Faustin Pascal Tsagué Manfo
  • Rajamanickam Jubendradass
  • Edouard Akono Nantia
  • Paul Fewou Moundipa
  • Premendu Prakash Mathur
Part of the Reviews of Environmental Contamination and Toxicology book series (RECT, volume 228)


Infertility is one of the major health problems that affect human sociocultural life. It affects 8–15 % of couples around the world, and about 50 % of infertility cases are attributed to male factors (WHO 1991; Cui 2010; Hamada et al. 2011). Among the factors that cause male infertility are exposures to environmental toxicants (Akingbemi et al. 2004). Bisphenol A ([2,2-bis(4-hydroxyphenyl)propane]: BPA) is among the most prominent of toxic environmental contaminants worldwide. The original synthesis of BPA is attributed to two scientists: Dianin, who is thought to have been the first to design the molecule in 1891, and Zincke, who reportedly synthesized the molecule in 1905 (Huang et al. 2011). Since then, BPA has been widely produced and used as a common ingredient in the manufacture of plastics. Plastics are broadly integrated into today’s lifestyle and make a major contribution to almost all product areas (Olea et al. 1996; Völkel et al. 2011; Hammer et al. 2012). The wide and heavy use of plastics has contributed to BPA having been spread throughout the environment.


Luteinizing Hormone Leydig Cell Sperm Count Luteinizing Hormone Receptor Tolerable Daily Intake 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was funded by the Federation of Indian Chambers of Commerce & Industry (FICCI), the Department of Science and Technology (DST), and Government of India, through CV Raman International Fellowship for African Researchers.


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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Faustin Pascal Tsagué Manfo
    • 1
  • Rajamanickam Jubendradass
    • 2
  • Edouard Akono Nantia
    • 3
  • Paul Fewou Moundipa
    • 4
  • Premendu Prakash Mathur
    • 2
    • 5
  1. 1.Department of Biochemistry and Molecular Biology, Faculty of ScienceUniversity of BueaBueaCameroon
  2. 2.Department of Biochemistry and Molecular Biology, School of Life SciencesPondicherry UniversityPondicherryIndia
  3. 3.Department of Biological Science, Faculty of ScienceUniversity of BamendaBambiliCameroon
  4. 4.Laboratory of Pharmacology and Toxicology, Department of Biochemistry, Faculty of ScienceUniversity of Yaoundé IYaoundéCameroon
  5. 5.KIIT UniversityBhubaneshwarIndia

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