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Analysis of Binding Residues between PDGF-BB and Epidermal Growth Factor Receptor: A Computational Docking Study

  • Ricardo Cabezas
  • Daniel Torrente
  • Marco Fidel Avila
  • Jannet González
  • George Emilio Barreto
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 232)

Abstract

A directed docking was performed using Cluspro between human PDGF-BB and EGFR using specific templates obtained from PDB. Various conserved residues were found to be involved in the docking interaction of the complex by means of hydrophobic interactions and hydrogen bonds. An electrostatic potential evaluation of the PDGF-BB-EGFR complex was also performed to validate if the complex is electrostatically complementary in the binding area. Results suggested a possible binding mechanism which could explain the in vivo evidence of formation of heterodimeric receptors EGFR-PDGFR.

Keywords

PDGF-BB EGFR docking Transactivation interactions 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Ricardo Cabezas
    • 1
  • Daniel Torrente
    • 1
  • Marco Fidel Avila
    • 1
  • Jannet González
    • 1
  • George Emilio Barreto
    • 1
  1. 1.School of Sciences, Department of Nutrition and BiochemistryPontificia Universidad JaverianaBogotáColombia

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