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Stability Analysis of Antimicrobial Peptides in Solvation Conditions by Molecular Dynamics

  • Daniel Osorio
  • Paola Rondón-Villarreal
  • Rodrigo Torres
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 232)

Abstract

Cationic antimicrobial peptides are a family of highly homologous proteins conserved in all multicellular organisms with great potential as broad-spectrum antibiotics. In this paper, we analyze the stability of the 3D structure of three antimicrobial peptides reported in CAMP database, working in solvation conditions at three pHs and three different temperatures. We found that one of the tested peptides did not form stable three-dimensional structure. For this reason, it is not expected a bactericidal action per se. The other peptides showed an α-helix conformation under certain conditions evaluated.

Keywords

AMP Antimicrobial peptides Stability 3D-Structure Molecular Dynamics 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Daniel Osorio
    • 1
  • Paola Rondón-Villarreal
    • 2
  • Rodrigo Torres
    • 3
  1. 1.Escuela de Biología, Facultad de CienciasUISBucaramangaColombia
  2. 2.Escuela de Ingeniería Eléctrica, Electrónica y Telecomunicaciones, Facultad de Ingenierías Físico-MecánicasUISBucaramangaColombia
  3. 3.Escuela de Química, Facultad de CienciasUniversidad Industrial de Santander (UIS)BucaramangaColombia

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