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Temporal Aspects of Ca2+ Signaling in Airway Myocytes

  • Etienne RouxEmail author
Chapter

Abstract

This chapter discusses how variation in intracytoplasmic Ca2+ concentration ([Ca2+]i) over time can be considered as a signal for the contractile machinery. It presents an overview of the literature that describes the Ca2+ response pattern to different contractile or relaxant agonists in several types of airway smooth muscle cells (ASMCs) depending on the species and location in the airway tree and recording methods, insisting on the temporal aspects of this response. Since the dynamics of the Ca2+ signal depends on the dynamics of the mechanisms responsible for this signal, the chapter presents an overview of the main mechanisms responsible for Ca2+ homeodynamics in ASMCs. By analyzing some examples, it shows how the kinetics of these mechanisms determine the pattern of the Ca2+ signal. The consequence of cell-to-cell variations in the Ca2+ signal is also discussed, with special attention to oscillatory versus nonoscillatory responses. The last part of the chapter presents the relationship between the parameter of the Ca2+ signal and the pattern of the contractile response. The mechanisms of the contractile apparatus itself will not be detailed, this question being beyond the scope of the chapter, but the temporal relationship between the Ca2+ signal and the subsequent contraction is analyzed.

Keywords

Calcium dynamics Oscillations Kinetics Model Contraction 

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© Springer International Publishing Switzerland 2014

Authors and Affiliations

  1. 1.Adaptation cardiovasculaire à l’ischémie INSERM U 1034University of BordeauxPessacFrance

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