Advertisement

Regulation of Contractility in Immature Airway Smooth Muscle

  • Y. S. PrakashEmail author
  • Christina M. Pabelick
  • Richard J. Martin
Chapter

Abstract

Airway smooth muscle (ASM) plays an important role in the regulation of airway tone at all stages of life. While there has been much examination of the mechanisms by which adult ASM contracts and relaxes, especially given its importance in diseases such as asthma, there has been substantially less exploration of immature ASM. Here, given the fact that embryonic/fetal and postnatal lung development is associated with substantial and rapid changes in airway structure and size, the immature ASM must maintain the capability to contract/relax as well as proliferate. Beyond this obvious physiological relevance, the clinical importance of understanding the developing ASM lies in its potential role in diseases of the newborn that predispose infants to adult problems such as asthma. In this chapter we briefly describe the current state of knowledge regarding immature ASM and mechanisms that regulate its contractility.

Keywords

Lung Embryology Premature birth Asthma Bronchopulmonary dysplasia 

Notes

Acknowledgments

This work was supported by National Institutes of Health Grant R01 HL056470 (YSP, RM) and the Flight Attendants Medical Research Institute (FAMRI; CMP).

References

  1. 1.
    Jesudason EC (2009) Airway smooth muscle: an architect of the lung? Thorax 64:541–5. doi:  10.1136/thx.2008.107094 PubMedCrossRefGoogle Scholar
  2. 2.
    Sparrow MP, Weichselbaum M and McCray PB (1999) Development of the innervation and airway smooth muscle in human fetal lung. Am J Respir Cell Mol Biol 20:550–60.PubMedCrossRefGoogle Scholar
  3. 3.
    Chitano P and Murphy TM (2003) Maturational changes in airway smooth muscle shortening and relaxation. Implications for asthma. Respir Physiol Neurobiol 137:347–59.PubMedCrossRefGoogle Scholar
  4. 4.
    Sparrow MP and Mitchell HW (1990) Contraction of smooth muscle of pig airway tissues from before birth to maturity. J Appl Physiol 68:468–77.PubMedGoogle Scholar
  5. 5.
    Duncan PG and Douglas JS (1985) Influences of gender and maturation on responses of guinea-pig airway tissues to LTD4. Eur J Pharmacol 112:423–7.PubMedCrossRefGoogle Scholar
  6. 6.
    Jude JA, Wylam ME, Walseth TF and Kannan MS (2008) Calcium signaling in airway smooth muscle. Proc Am Thorac Soc 5:15–22. doi: 5/1/15 [pii] 10.1513/pats.200704-047VSGoogle Scholar
  7. 7.
    Pabelick CM, Sieck GC and Prakash YS (2001) Invited review: significance of spatial and temporal heterogeneity of calcium transients in smooth muscle. J Appl Physiol 91:488–96.PubMedGoogle Scholar
  8. 8.
    White TA, Xue A, Chini EN, Thompson M, Sieck GC and Wylam ME (2006) Role of transient receptor potential C3 in TNF-alpha-enhanced calcium influx in human airway myocytes. Am J Respir Cell Mol Biol 35:243–51. doi: 2006-0003OC [pii] 10.1165/rcmb.2006-0003OCGoogle Scholar
  9. 9.
    Mahn K, Ojo OO, Chadwick G, Aaronson PI, Ward JP and Lee TH (2010) Ca2+ homeostasis and structural and functional remodelling of airway smooth muscle in asthma. Thorax 65:547–52. doi: 65/6/547 [pii] 10.1136/thx.2009.129296Google Scholar
  10. 10.
    Sanderson MJ, Delmotte P, Bai Y and Perez-Zogbhi JF (2008) Regulation of airway smooth muscle cell contractility by Ca2+ signaling and sensitivity. Proc Am Thorac Soc 5:23–31. doi: 5/1/23 [pii] 10.1513/pats.200704-050VSGoogle Scholar
  11. 11.
    McCray PB, Jr. (1993) Spontaneous contractility of human fetal airway smooth muscle. Am J Respir Cell Mol Biol 8:573–80.PubMedCrossRefGoogle Scholar
  12. 12.
    Featherstone NC, Jesudason EC, Connell MG, Fernig DG, Wray S, Losty PD and Burdyga TV (2005) Spontaneous propagating calcium waves underpin airway peristalsis in embryonic rat lung. Am J Respir Cell Mol Biol 33:153–60. doi:  10.1165/rcmb.2005-0137OC PubMedCrossRefGoogle Scholar
  13. 13.
    Jesudason EC, Smith NP, Connell MG, Spiller DG, White MR, Fernig DG and Losty PD (2006) Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth. Am J Physiol Lung Cell Mol Physiol 291:L559-65. doi:  10.1152/ajplung.00498.2005 PubMedCrossRefGoogle Scholar
  14. 14.
    Sieck GC, Han YS, Pabelick CM and Prakash YS (2001) Temporal aspects of excitation-contraction coupling in airway smooth muscle. J Appl Physiol 91:2266–74.PubMedGoogle Scholar
  15. 15.
    Rosenberg SM, Berry GT, Yandrasitz JR and Grunstein MM (1991) Maturational regulation of inositol 1,4,5-trisphosphate metabolism in rabbit airway smooth muscle. J Clin Invest 88:2032–8. doi:  10.1172/JCI115531 PubMedCrossRefGoogle Scholar
  16. 16.
    Schramm CM, Chuang ST and Grunstein MM (1992) Maturation of inositol 1,4,5-trisphosphate receptor binding in rabbit tracheal smooth muscle. Am J Physiol 263:L501–5.PubMedGoogle Scholar
  17. 17.
    Grunstein MM, Rosenberg SM, Schramm CM and Pawlowski NA (1991) Mechanisms of action of endothelin 1 in maturing rabbit airway smooth muscle. Am J Physiol 260:L434–43.PubMedGoogle Scholar
  18. 18.
    Souhrada M, Rothberg KG and Douglas JS (1988) Membrane properties of bovine airway smooth muscle cells: effects of maturation. Pulm Pharmacol 1:47–52.PubMedCrossRefGoogle Scholar
  19. 19.
    Pichoff BE, Uyehara CF and Nakamura KT (1993) Effect of calcium agonists, BAY K 8644 and CGP 28392, on guinea pig airway smooth muscle function during development. J Pharmacol Exp Ther 265:524–8.PubMedGoogle Scholar
  20. 20.
    Hartman WR, Smelter DF, Sathish V, Karass M, Kim S, Aravamudan B, Thompson MA, Amrani Y, Pandya HC, Martin RJ, Prakash YS and Pabelick CM (2012) Oxygen-Dose Responsiveness of Human Fetal Airway Smooth Muscle Cells. Am J Physiol Lung Cell Mol Physiol. doi:  10.1152/ajplung.00037.2012 PubMedGoogle Scholar
  21. 21.
    Jobe AH (2010) The new bronchopulmonary dysplasia. Current opinion in pediatrics. doi:  10.1097/MOP.0b013e3283423e6b Google Scholar
  22. 22.
    Hershenson MB, Aghili S, Punjabi N, Hernandez C, Ray DW, Garland A, Glagov S and Solway J (1992) Hyperoxia-induced airway hyperresponsiveness and remodeling in immature rats. The American journal of physiology 262:L263–9.PubMedGoogle Scholar
  23. 23.
    Colasurdo GN, Loader JE, Graves JP and Larsen GL (1994) Maturation of nonadrenergic noncholinergic inhibitory system in normal and allergen-sensitized rabbits. Am J Physiol 267:L739–44.PubMedGoogle Scholar
  24. 24.
    Mhanna MJ, Dreshaj IA, Haxhiu MA and Martin RJ (1999) Mechanism for substance P-induced relaxation of precontracted airway smooth muscle during development. Am J Physiol 276:L51–6.PubMedGoogle Scholar
  25. 25.
    Chitano P, Cox CM and Murphy TM (2002) Relaxation of guinea pig trachealis during electrical field stimulation increases with age. J Appl Physiol 92:1835–42. doi:  10.1152/japplphysiol.00688.2001 PubMedGoogle Scholar

Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Y. S. Prakash
    • 1
    • 2
    Email author
  • Christina M. Pabelick
    • 1
    • 2
  • Richard J. Martin
    • 3
  1. 1.Mayo ClinicRochesterUSA
  2. 2.Departments of Anesthesiology and Physiology and Biomedical EngineeringCollege of Medicine, Mayo ClinicRochesterUSA
  3. 3.Department of Pediatrics, Division of NeonatologyRainbow Babies Children’s Hospital, Case Western Reserve UniversityClevelandUSA

Personalised recommendations