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Role of Caveolae in the Airway

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Calcium Signaling In Airway Smooth Muscle Cells

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Abstract

Caveolae are flask-shaped invaginations of the plasma membrane that are rich in lipids and serve as microdomains to facilitate interactions between proteins at the membrane as well as intracellular components, thus modulating signal transduction, protein and lipid transport, and other processes. Constituent caveolar proteins such as caveolins and cavins also have scaffolding domains that anchor and regulate protein function. There is now evidence that caveolae and their constituent proteins are present in airway smooth muscle in a variety of species. Caveolae in airway cells contain or interact with molecules such as receptors, ion channels, and regulatory proteins that are key to the roles of airway epithelium and smooth muscle in regulating airway structure and function. Furthermore, caveolar protein expression and regulation appear to be important in mediating and modulating the effects of inflammation on the airway, thereby contributing to the pathophysiology of diseases such as asthma.

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Authors and Affiliations

  1. Department of Anesthesiology, Mayo Clinic, 4-184 W Joseph SMH, Rochester, MN, 55905, USA

    Christina M. Pabelick M.D. & Y. S. Prakash M.D., Ph.D.

  2. Department of Physiology and Biomedical Engineering, Mayo Clinic, 4-184 W Joseph SMH, Rochester, MN, 55905, USA

    Christina M. Pabelick M.D. & Y. S. Prakash M.D., Ph.D.

  3. Department of Biochemistry and Molecular Biology, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA

    Brij B. Singh Ph.D.

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  1. Christina M. Pabelick M.D.
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  2. Brij B. Singh Ph.D.
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  3. Y. S. Prakash M.D., Ph.D.
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Correspondence to Christina M. Pabelick M.D. .

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Editors and Affiliations

  1. Albany Medical College Center for Cardiovascular Sciences, Albany, New York, USA

    Yong-Xiao Wang

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Pabelick, C.M., Singh, B.B., Prakash, Y.S. (2014). Role of Caveolae in the Airway. In: Wang, YX. (eds) Calcium Signaling In Airway Smooth Muscle Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-01312-1_12

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