Abstract
Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are the most important Ca2+ release channels on the sarcoplasmic (or endoplasmic) reticulum (SR) in almost all types of cells. In the past several decades, the studies of RyRs and IP3Rs have greatly facilitated our understanding of the physiological functions and pathological mechanisms for various diseases including heart failure, arrhythmias, myopathy, and seizure. Similarly, their important roles have been explored in airway smooth muscle cells (SMCs). These two receptors control intracellular Ca2+ release and modulate extracellular Ca2+ influx, thereby playing an essential role in cell contraction, relaxation, proliferation, migration, metabolism, and, ultimately, cell fate. The abnormality of Ca2+ signaling in airway SMCs may contribute to the development of multiple lung diseases, notably asthma. Concomitantly, many regulators, including Ca2+ itself, calmodulin, protein kinases, FK506-binding protein 12.6 (FKBP12.6), cyclic adenosine diphosphate ribose (cADPR), and redox status, are involved in the regulation of Ca2+ signaling and, thus, the physiological function and pathological alterations. The two SR Ca2+ release channels may also directly or indirectly interact with plasmalemmal and mitochondrial ion channels such as transient receptor potential cation, big-conductance Ca2+-activated K+, Ca2+-activated Cl−, and other channels, providing positive or negative feedback mechanisms to control Ca2+ signaling and cellular functions.
Keywords
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- 2-APB:
-
2-aminoethoxy-diphenylborate
- ACh:
-
Acetylcholine
- BKCa :
-
Big-conductance Ca2+-activated K+ channel
- cADPR:
-
Cyclic adenosine diphosphate ribose
- CaMKII:
-
Calmodulin-dependent protein kinase II
- CICR:
-
Ca2+-induced Ca2+ release
- ClCa :
-
Ca2+-activated Cl− channel
- CPVT:
-
Catecholaminergic polymorphic ventricular tachycardia
- DAG:
-
Diacylglycerol
- FKBP12.6:
-
FK506-binding protein 12.6
- GPX1:
-
Glutathione peroxidase-1
- H2O2 :
-
Hydrogen peroxide
- IL-13:
-
Interleukin-13
- IP3Rs:
-
Inositol 1,4,5-trisphosphate receptors
- IRAG:
-
cGMP kinase substrate
- LTCCs:
-
L-type voltage-gated Ca2+ channels
- LTD4:
-
Leukotriene D4
- M3R:
-
Muscarinic M3 receptor
- mACh:
-
Methacholine
- MLC:
-
Myosin light chain
- MLCK:
-
Myosin light chain kinase
- MLCP:
-
Myosin light chain phosphatase
- mTOR:
-
Mammalian target of rapamycin
- NCX:
-
Na+/Ca2+ exchanger
- NO:
-
Nitric oxide
- NSCCs:
-
Nonselective cation channels
- PI3K:
-
Phosphatidylinositol 3 kinases
- PIP2:
-
Phosphatidylinositol 4 5-bisphosphate
- PKA:
-
Protein kinase A
- PKC:
-
Protein kinase C
- PKG:
-
cGMP-dependent protein kinase
- PLC:
-
Phospholipase C
- ROS:
-
Reactive oxygen species
- RyR:
-
Ryanodine receptor
- SERCA:
-
Sarcoplasmic reticulum Ca2+ ATPase
- SMC:
-
Smooth muscle cell
- SOCE:
-
Store-operated calcium entry
- SR:
-
Sarcoplasmic reticulum
- STIC:
-
Spontaneous transient inward current
- STOC:
-
Spontaneous transient outward current
- TNF-α:
-
Tumor necrosis factor-α
- TRP:
-
Transient receptor potential channel
- VICR:
-
Voltage-induced Ca2+ release
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Mei, L., Zheng, YM., Wang, YX. (2014). Ryanodine and Inositol Trisphosphate Receptors/Ca2+ Release Channels in Airway Smooth Muscle Cells. In: Wang, YX. (eds) Calcium Signaling In Airway Smooth Muscle Cells. Springer, Cham. https://doi.org/10.1007/978-3-319-01312-1_1
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