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Registration of Small-Animal SPECT/MRI Studies for Tracking Human Mesenchymal Stem Cells

  • V. García-Vázquez
  • L. Cussó
  • J. Chamorro-Servent
  • I. Mirones
  • J. García-Castro
  • L. López-Sánchez
  • S. Peña-Zalbidea
  • P. Montesinos
  • C. Chavarrías
  • J. Pascau
  • M. Desco
Part of the IFMBE Proceedings book series (IFMBE, volume 41)

Abstract

Single-photon emission computed tomography (SPECT) offers the possibility to study the biodistribution of 111In-labeled human mesenchymal stem cells (hMSCs). This functional information can be complemented by magnetic resonance imaging (MRI) that provides the anatomical context to the SPECT image. However, acquiring such studies with separate SPECT/MRI systems requires a multimodality registration in order to fuse both images. In this work, a special bed was designed based on three non-coplanar glass capillary tubes filled with a mixture of 99mTc and CuSO4, visible in both modalities. Moreover, it was necessary to design a semi-automated rigid registration procedure based on matching these rods by minimizing the distance between corresponding lines. The maximum target registration error achieved was 0.9 mm, in the range of SPECT resolution.

Keywords

Registration SPECT/MRI mouse multimodality 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • V. García-Vázquez
    • 1
    • 2
  • L. Cussó
    • 1
    • 2
    • 3
  • J. Chamorro-Servent
    • 2
    • 3
  • I. Mirones
    • 4
  • J. García-Castro
    • 4
  • L. López-Sánchez
    • 2
    • 3
  • S. Peña-Zalbidea
    • 2
  • P. Montesinos
    • 2
    • 3
  • C. Chavarrías
    • 2
  • J. Pascau
    • 2
    • 3
  • M. Desco
    • 2
    • 3
  1. 1.Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM)MadridSpain
  2. 2.Instituto de Investigación Sanitaria Gregorio MarañónMadridSpain
  3. 3.Departamento de Bioingeniería e Ingeniería AeroespacialUniversidad Carlos III de MadridMadridSpain
  4. 4.Unidad de Biotecnología Celular (Área de Genética Humana, IIER)Instituto de Salud Carlos IIIMadridSpain

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