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Quantitative Assessment of Prenatal AorticWall Thickness in Gestational Diabetes

  • Elisa Veronese
  • Silvia Visentin
  • Marius Linguraru
  • Erich Cosmi
  • Enrico Grisan
Part of the IFMBE Proceedings book series (IFMBE, volume 41)

Abstract

Intrauterine environment, and especially a mismatch between the early and later-life environments, is thought to induce epigenetic and morphological changes that may manifest in later life as an increased vulnerability to non communicable diseases as diabetes. Prenatal events, such as intrauterine growth restriction, as well as an increased risk of developing diabetes and cardiovascular alterations, have been shown to be associated with an increased intima-media thickness (aIMT) of the abdominal aorta in the fetus. To date its measure, has been performed manually on ultrasound fetal images by skilled practitioners.We present an automatic algorithm that identifies abdominal aorta and estimates its diameter and thickness from routine third trimester ultrasonographic fetal data, providing a correlation between end-diastole aIMT automatic and manual measures of 0.96, with a mean error of 0.02 mm, and a relative error of 3%.

Moreover, we show preliminary results on the application of the algorithm, proving a significant difference aIMT values between fetuses with normal weight and those with normal weight but gestational diabetic mother.

Keywords

Segmentation Mixture models B-mode ultrasound Fetal ultrasound Intima-media thickness Gestational diabetes Diabetes 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Elisa Veronese
    • 1
  • Silvia Visentin
    • 2
  • Marius Linguraru
    • 3
  • Erich Cosmi
    • 2
  • Enrico Grisan
    • 1
  1. 1.Department of Information EngineeringUniversity of PadovaPadovaItaly
  2. 2.Department of Woman and Child HealthUniversity Hospital of PadovaPadovaItaly
  3. 3.Children’s National Medical Center Sheikh Zayed Institute for Pediatric Surgical InnovationWashington DCUSA

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