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Network-Based Modular Markers of Aging across Different Tissues

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Part of the IFMBE Proceedings book series (IFMBE,volume 41)

Abstract

Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.

Keywords

  • aging
  • module
  • protein interaction
  • microarray

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  • DOI: 10.1007/978-3-319-00846-2_456
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© 2014 Springer International Publishing Switzerland

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Vrahatis, A.G., Dimitrakopoulou, K., Dimitrakopoulos, G.N., Sgarbas, K.N., Tsakalidis, A.K., Bezerianos, A. (2014). Network-Based Modular Markers of Aging across Different Tissues. In: Roa Romero, L. (eds) XIII Mediterranean Conference on Medical and Biological Engineering and Computing 2013. IFMBE Proceedings, vol 41. Springer, Cham. https://doi.org/10.1007/978-3-319-00846-2_456

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  • DOI: https://doi.org/10.1007/978-3-319-00846-2_456

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-00845-5

  • Online ISBN: 978-3-319-00846-2

  • eBook Packages: EngineeringEngineering (R0)