Network-Based Modular Markers of Aging across Different Tissues

  • Aristidis G. Vrahatis
  • Konstantina Dimitrakopoulou
  • Georgios N. Dimitrakopoulos
  • Kyriakos N. Sgarbas
  • Athanasios K. Tsakalidis
  • Anastasios Bezerianos
Part of the IFMBE Proceedings book series (IFMBE, volume 41)

Abstract

Aging is a highly complex biological process and a risk factor for many diseases. Motivated by the high availability of diverse high-throughput data in the mouse model organism, we provide a systemic view of the age-related mechanisms. In particular, we present a robust network-based integrative approach that provides, based on protein interaction and microarray data, reliable modules that alter significantly in terms of expression during aging. Our modular meta-analysis provides novel information about the involvement of several established as well as recently reported longevity-associated pathways across different tissues.

Keywords

aging module protein interaction microarray 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • Aristidis G. Vrahatis
    • 1
  • Konstantina Dimitrakopoulou
    • 2
  • Georgios N. Dimitrakopoulos
    • 3
  • Kyriakos N. Sgarbas
    • 3
  • Athanasios K. Tsakalidis
    • 1
  • Anastasios Bezerianos
    • 2
    • 4
  1. 1.Department of Computer Engineering and InformaticsUniversity of PatrasPatrasGreece
  2. 2.School of MedicineUniversity of PatrasPatrasGreece
  3. 3.Department of Electrical and Computer EngineeringUniversity of PatrasPatrasGreece
  4. 4.SINAPSE Institute, Center of Life SciencesNational University of SingaporeSingaporeSingapore

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