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Graph-Theoretical Analysis in Schizophrenia Performing an Auditory Oddball Task

  • A. Bachiller
  • J. Poza
  • C. Gómez
  • V. Molina
  • V. Suazo
  • A Díez
  • R. Hornero
Part of the IFMBE Proceedings book series (IFMBE, volume 41)

Abstract

The aim of this research was to study the organization of the brain functional network during an auditory oddball task in schizophrenia (SZ). Electroencephalographic (EEG) activity was recorded from 31 schizophrenic patients and 38 healthy controls. In a first step, coherence was used to estimate the similarity between the spectral content of each pair of electrodes. In a second step, a graph was generated from the similarity matrix and two network parameters were computed: the clustering coefficient and the path length. Our results indicate that SZ patients obtained lower clustering coefficient and longer path length variations between the baseline and the P300 response than controls. These findings suggest an abnormal organization of the brain functional network in SZ.

Keywords

Schizophrenia coherence graph network clustering coefficient path length 

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Copyright information

© Springer International Publishing Switzerland 2014

Authors and Affiliations

  • A. Bachiller
    • 1
  • J. Poza
    • 1
  • C. Gómez
    • 1
  • V. Molina
    • 2
  • V. Suazo
    • 3
  • A Díez
    • 3
  • R. Hornero
    • 1
  1. 1.Biomedical Engineering Group (GIB), Dpt. TSCITUniversity of ValladolidValladolidSpain
  2. 2.Psychiatry Department, Faculty of MedicineUniversity of ValladolidValladolidSpain
  3. 3.Institute of Biomedical Research (IBSAL)SalamancaSpain

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