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Assignment of Novel Functions to Helicobacter pylori 26695’s Genome

  • Tiago Resende
  • Daniela M. Correia
  • Isabel Rocha
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 222)

Abstract

Helicobacter pylori is a pathogenic bacterium that colonizes the human epithelia, causing duodenal and gastric ulcers as well as gastric cancer. The genome of H. pylori 26695 has been sequenced and annotated. In addition, two genome-scale metabolic models have been developed. In order to maintain accurate and relevant information on coding sequences (CDS) and to retrieve new information, the assignment of new functions to Helicobacter pylori 26695’s genes was performed. The use of software tools, on-line databases and an annotation pipeline for inspecting each gene allowed the attribution of validated E.C. numbers to metabolic genes, and the assignment of 177 new functions to the CDS of this bacterium. This information provides relevant biological information for the scientific community dealing with this organism and can be used as the basis for a new metabolic model reconstruction.

Keywords

Helicobacter pylori Genome annotation Metabolic functions Genome-Scale Reconstruction 

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Tiago Resende
    • 1
  • Daniela M. Correia
    • 1
  • Isabel Rocha
    • 1
  1. 1.IBB – Institute for Biotechnology and Bioengineering, Centre of Biological EngineeringUniversity of MinhoMinhoPortugal

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