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HaptreeBuilder: Web Generation and Visualization of Risk Haplotype Trees

  • Dimitra Kamari
  • María Mar Abad-Grau
  • Fuencisla Matesanz
Part of the Advances in Intelligent Systems and Computing book series (AISC, volume 222)

Abstract

The quantity and quality of genome-wide association studies for several diseases are constantly increasing. As a consequence, molecular biologists from different laboratories demand new visualization tools for them to explore results by view and formulate new conjectures to work on. Although nowadays most studies are not able to reconstruct individual haplotypes, the next generation sequencying technologies will allow to obtain individual haplotypes in most studies conducted in the next few years. As evolutionary analysis of the haplotypes can be an invaluable information to biomedical researchers to build hypotheses of genetic variation by considering haplotype evolution, we have build a web-based tool for biomedical researchers to build and visualize risk haplotype trees along a chromosome so that they can perform a visual online exploration of the genetic factors associated with complex diseases.

Keywords

genome-wide association study haplotype disease risk next generation sequencing 

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Copyright information

© Springer International Publishing Switzerland 2013

Authors and Affiliations

  • Dimitra Kamari
    • 1
  • María Mar Abad-Grau
    • 2
  • Fuencisla Matesanz
    • 3
  1. 1.Department of Computer Engineering and InformaticsUniversity of PatrasPatrasGreece
  2. 2.Department of Computer Languages and SystemsCITIC - University of GranadaGranadaSpain
  3. 3.Instituto de Parasitología López NeyraCSICGranadaSpain

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