Glycyrrhiza uralensis 甘草 (Gancao, Licorice)

  • Sue-Joan ChangEmail author
  • Yin-Ching Chan
  • Wen-Jen Yu


Licorice (Gan-Cao) is a perennial herb of Fabaceae family cultivated mainly in Shanxi, Gansu and Xinjiang regions of China. “Gan” of licorice in Chinese means umami taste of licorice, therefore, licorice is an important constituent in many traditional Chinese medicine (TCM) to reduce the bitter taste of other herbal medicine. The height of licorice plant for medicinal use is 30–100 cm. The medicinal part of licorice is the cylinder root and underground stem with a diameter of approximately 3–4 cm.


Traditional Chinese Medicine Glycyrrhizic Acid Chronic Unpredictable Stress Glycyrrhetinic Acid Normal Human Dermal Fibroblast 
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  1. 1.
    Pharmacopoeia Committee of P. R. China (2010) Pharmacopoeia of People’s Republic of China. Chemical Industry Publishers, BeijingGoogle Scholar
  2. 2.
    Walker BR, Edwards CRW (1991) 11 Beta-hydroxysteroid dehydrogenase and enzyme-mediated receptor protection: life after liquorice? Clin Endocrinol 35(4):281–289CrossRefGoogle Scholar
  3. 3.
    Akamatus H et al (1991) Mechanism of anti-inflammatory action of glycyrrhizin: effect on neutrophil functions including reactive oxygen species generation. Planta Med 57(2):119–121CrossRefGoogle Scholar
  4. 4.
    Zakirov NU et al (1999) The cardioprotective action of 18-dehydroglycyrrhetic acid in experimental myocardial damage. Eksp Klin Farmakol 62(2):19–21Google Scholar
  5. 5.
    Tsukshara M et al (2005) Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E(2) production in normal human dermal fibroblasts. Chem Pharm Bull 53(9):1103–1110CrossRefGoogle Scholar
  6. 6.
    Wang J et al (2013) Glycyrrhizic acid as the antiviral component of Glycyrrhiza uralensis Fisch. Against coxsackievirus A16 and enterovirus 71 of hand foot and mouth disease. J Ethnopharmacol 147(1):114–121CrossRefGoogle Scholar
  7. 7.
    Wang W et al (2013) Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid. Int J Nanomedicine 8:1377–1383Google Scholar
  8. 8.
    Alfajaro MM et al (2012) Anti-rotaviral effects of Glycyrrhiza uralensis extract in piglets with rotavirus diarrhea. Virol J 9:310CrossRefGoogle Scholar
  9. 9.
    Yoshida M et al (2012) Inhibitory effects of glycyrrhetinic acid on DNA polymerase and inflammatory activities. Evid Based Complement Alternat Med. doi: 10.1155/2012/650514 Google Scholar
  10. 10.
    Knipping K, Garssen J (2012) An evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. Virol J 9:137CrossRefGoogle Scholar
  11. 11.
    Huo HZ et al (2011) Hepatoprotective and antioxidant effects of licorice extract against CCl4-induced oxidative damage in rats. Int J Mol Sci 12(10):6529–6543CrossRefGoogle Scholar
  12. 12.
    Raphael TJ, Kuttan G (2003) Effect of naturally occurring triterpenoids glycyrrhizic acid, ursolic acid, oleanolic acid and nomilin on the immune system. Phytomedicine 10(6–7):483–489CrossRefGoogle Scholar
  13. 13.
    Barfod L et al (2002) Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines. Int Immunopharmacol 2(4):545–555CrossRefGoogle Scholar
  14. 14.
    Kimura M et al (1992) Selective activation of extrathymic T cells in the liver by glycyrrhizin. Biotherapy 5(3):167–176CrossRefGoogle Scholar
  15. 15.
    Ishiwata S et al (1999) Fas-mediated apoptosis is enhanced by glycyrrhizin without alteration of caspase-3-like activity. Biol Pharm Bull 22(11):1163–1166CrossRefGoogle Scholar
  16. 16.
    Yang N et al (2013) Glycyrrhiza uralensis flavonoids present in anti-asthma formula, ASHMI (TM), inhibit memory Th2 responses in vitro and in vivo. Phytother Res 27(9):1381–1391CrossRefGoogle Scholar
  17. 17.
    Li XM et al (2009) Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblast in vitro. J Agric Food Chem 57(3):820–825CrossRefGoogle Scholar
  18. 18.
    Jo EH et al (2005) Chemopreventive properties of the ethanol extract of Chinese licorice (Glycyrrhiza uralensis) root: induction of apoptosis and G1 cell cycle arrest in MCF-7 human breast cancer cells. Cancer Lett 230(2):239–247CrossRefGoogle Scholar
  19. 19.
    Salvi M et al (2003) Glycyrrhetinic acid-induced permeability transition in rat liver mitochondria. Biochem Pharmacol 66(12):2375–2379CrossRefGoogle Scholar
  20. 20.
    Fiore C et al (2004) On the mechanism of mitochondrial permeability transition induction by glycyrrhetinic acid. Biochim Biophys Acta 1658(3):195–201CrossRefGoogle Scholar
  21. 21.
    Fan ZZ (2012) Antidepressant activities of flavonoids from Glycyrrhiza uralensis and its neurogenesis protective effect in rats. Acta Pharm Sinica 47(12):1612–1617Google Scholar
  22. 22.
    Lee HK (2012) Inhibitory effects of Glycyrrhizae radix and its active component, isoliquiritigenin, on Aβ (25-35)-induced neurotoxicity in cultured rat cortical neurons. Arch Pharm Res 35(5):897–904CrossRefGoogle Scholar
  23. 23.
    Yang EJ et al (2012) Isoliquiritigenin isolated from Glycyrrhiza uralensis protects neuronal cells against glutamate-induced mitochondrial dysfunction. Biochem Biophys Res Commun 421(4):658–664CrossRefGoogle Scholar
  24. 24.
    Hajirahimkhan A et al (2013) Evaluation of estrogenic activity of licorice species in comparison with hops used in botanicals for menopausal symptoms. PLoS ONE 8(7):e67947CrossRefGoogle Scholar
  25. 25.
    Yin C et al (2010) Effects of glycyrrhizic acid on peroxisome proliferator-activated receptor gamma (PPARγ), lipoprotein lipase (LPL), serum lipid and HOMA-IR in rats. PPAR Res. doi: 10.1155/2010/530265 Google Scholar
  26. 26.
    Feng L et al (2013) Protection of glycyrrhizic acid against AGEs-induced endothelial dysfunction through inhibiting RAGE/NF-κB pathway activation in human umbilical vein endothelial cells. J Ethnopharmacol 148(1):27–36CrossRefGoogle Scholar
  27. 27.
    Camporesi HR et al (2012) Licorice abuse: time to send a warning message. Ther Adv Endocrinol Metab 3(4):125–138CrossRefGoogle Scholar
  28. 28.
    Levy C et al (2004) Use of herbal supplements for chronic liver disease. Clin Gastroenterol Hepatol 2(11):947–956CrossRefGoogle Scholar
  29. 29.
    Shibata S (2000) A drug over the millennia: pharmacognosy, chemistry, and pharmacology of licorice. Yakugaku Zasshi 120(10):849–862Google Scholar
  30. 30.
    Prete A et al (2012) Herbal products: benefits, limits, and applications in chronic liver disease. Evid Based Complement Alternat Med. doi: 10.1155/2012/837939 Google Scholar
  31. 31.
    Raveendra KR et al (2012) An extract of Glycyrrhiza Glabra (GutGard) alleviates symptoms of functional dyspepsia: a randomized, double-blind, placebo-controlled sudy. Evid Based Complement Alternat Med. doi: 10.1155/2012/216970 Google Scholar
  32. 32.
    Hajiaghamohammadi AA et al (2012) The efficacy of licorice root extract in decreasing transaminase activities in non-alcoholic fatty liver disease: a randomized controlled clinical trial. Phytother Res 26(9):1381–1384CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.Department of Life SciencesNational Cheng Kung UniversityTainanTaiwan
  2. 2.Department of Food and NutritionProvidence UniversityTaichungTaiwan
  3. 3.Department of BiotechnologyHung Kuang UniversityTaichungTaiwan

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