Abstract
In the skin, the squamous epithelial layer of the epidermis and the connective tissue of the underlying dermis are firmly connected to each other as illustrated in panels A and B. The structural arrangement of their interface, the dermal-epidermal junction, provides an illuminating example of how these two tissue components are linked together.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Borradori L and Sonnenberg A (1996) Hemidesmosomes: roles in adhesion, signaling and human diseases. Curr Opin Cell Biol 8: 647
Burgeson R and Christiano A (1997) The dermal-epidermal junction. Curr Opin Cell Biol 9: 651
Dowling J, Yu QC, and Fuchs E (1996) Beta 4 integrin is required for hemidesmosome formation, cell adhesion and cell survival. J Cell Biol 134: 559
Green K and Gaudry C (2000) Are desmosomes more than tethers for intermediate filaments? Nat Rev Mol Cell Biol 1: 208
Jones J, Hopkinson S, and Goldfinger L (1998) Structure and assembly of hemidesmosomes. Bioessays 20: 488
Kowalczyk A, Bornslaeger E, Norvell S, Palka H, and Green KJ (1999) Desmosomes: intercellular adhesive junctions specialised for attachment of intermediate filaments. Int Rev Cytol 185: 237
Mainiero F, Pepe A, Wary K, Spinardi L, Mohammadi M, Schlessinger J, and Giancotti F (1995) Signal transduction by the α6β4 integrin: Distinct β4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes. EMBO J 14: 4470
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer-Verlag/Wien
About this chapter
Cite this chapter
Pavelka, M., Roth, J. (2010). Skin Basement Membrane and Keratinocyte Hemidesmosomes: An Epithel-Connective Tissue Junctional Complex. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_98
Download citation
DOI: https://doi.org/10.1007/978-3-211-99390-3_98
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99389-7
Online ISBN: 978-3-211-99390-3
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)