Abstract
Neutrophilic leukocytes and naïve lymphocytes may interact in a specific manner with the endothelial cells lining the capillaries in various organs. This occurs during physiological recirculation (or homing) of lymphoid cells and diapedesis (extravasation) of leukocytes, and during infection or injury as well as inflammation by interaction of these cells with the activated endothelium. For this cell-cell interaction to occur, selectins and cell-surface glycans (as ligands) are important.
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References
Denucci CC, Mitchell JS, and Shimizu Y (2009) Integrin function in T-cell homing to lymphoid and non-lymphoid sites: getting there and staying there. Crit Rev Immunol 29: 87
Ley K, Laudanna C, Cybulsky MI, and Nourshargh S (2007) Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol 7: 678
Mulligan MS, Polley MJ, Bayer RJ, Nunn MF, Paulson JC, and Ward PA (1992) Neutrophil-dependent acute lung injury — requirement for P-selectin (GMP-140). J Clin Invest 90: 1600
Polley MJ, Phillips ML, Wayner E, Nudelman E, Singhal AK, Hakomori S, and Paulson JC (1991) CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proc Natl Acad Sci USA 88: 6224
Rosen SD (2004) Ligands for L-selectin: Homing, inflammation, and beyond. Annu Rev Immunol 22: 129
Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration — the multistep paradigm. Cell 76: 301
True DD, Singer MS, Lasky LA, and Rosen SD (1990) Requirement for sialic acid on the endothelial ligand of a lymphocyte homing receptor. J Cell Biol 111: 2757
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Pavelka, M., Roth, J. (2010). Selectin — Ligand-Mediated Cell-Cell Interaction. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_91
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DOI: https://doi.org/10.1007/978-3-211-99390-3_91
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99389-7
Online ISBN: 978-3-211-99390-3
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