Abstract
Particular glycans exhibit spatiotemporal expression patterns during embryonic development and may become re-expressed in malignant human tumours. Carcinoma-associated cell surface glycans can be involved in invasive and metastatic growth or of clinical importance as predictive markers. A commonly observed change is the increased synthesis of β1,6-branched tri- and tetra-antennary glycans. This correlates with the metastatic potential of certain tumours and is an independent predictive marker in colon carcinoma. Sialylated glycans terminated in α2,6-linked sialic acid or the sialosyl Tn antigen are associated with colon carcinoma progression and of predictive value. These findings, however, cannot be generalised.
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Pavelka, M., Roth, J. (2010). Glycocalyx Changes in Tumours. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_86
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DOI: https://doi.org/10.1007/978-3-211-99390-3_86
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99389-7
Online ISBN: 978-3-211-99390-3
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