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Russell Bodies and Aggresomes Represent Different Types of Protein Inclusion Bodies

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Abstract

It has already been mentioned that Russell bodies result from the aggregation of misfolded glycoproteins in the lumen of the rough endoplasmic reticulum. A giant Russell body similar in size to the nucleus is seen in panel A with normal appearing rough endoplasmic reticulum (RER), mitochondria (M), and secondary lysosomes (Ly). A main structural feature is its limiting membrane studded with ribosomes, the endoplasmic reticulum membrane.

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Pavelka, M., Roth, J. (2010). Russell Bodies and Aggresomes Represent Different Types of Protein Inclusion Bodies. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_22

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