Abstract
Monocytes are the largest in the class of leukocytes, and make up 2–8% of total leukocytes in the blood. They are bone marrow-derived and are the precursor cells of macrophages, and phagocytes of the mononuclear phagocytic system that are present in many tissues and organs, such as the alveolar phagocytes in the lung, the Kupffer cells in the liver (cf. Fig. 106), the histiocytes in the connective tissues, the microglial cells in the brain, and the phagocytes in the red pulp of the spleen that remove the senescent erythrocytes. Among the blood monocytes, also precursors of osteoclasts (cf. Fig. 148) are counted. Monocytes travel from the bone marrow to the diverse organs. They are transported in the blood, where they still remain a few days. Further differentiation of monocytes and transformation into phagocytic cells occurs outside the blood vessels. They infiltrate almost every tissue of the body.
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Pavelka, M., Roth, J. (2010). Monocyte. In: Functional Ultrastructure. Springer, Vienna. https://doi.org/10.1007/978-3-211-99390-3_178
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DOI: https://doi.org/10.1007/978-3-211-99390-3_178
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-99389-7
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