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Age-Dependent Changes in Dopaminergic Neuron Firing Patterns in Substantia Nigra Pars Compacta

  • Yoshiyuki IshidaEmail author
  • Tatsuya Kozaki
  • Yoshikazu Isomura
  • Sachiko Ito
  • Ken-ichi Isobe
Chapter
Part of the Journal of Neural Transmission. Supplementa book series (NEURALTRANS, volume 73)

Abstract

Dopaminergic neurons in the substantia nigra pars compacta modulate complex motor control. Nigral dopaminergic neurons exhibit three different firing patterns in vivo: a pacemaker mode, a random mode, and a burst mode. These firing patterns are closely related to motor control. However, the changes in the proportion of the firing patterns with respect to age have not been fully established. To clarify the age-dependent changes in the proportion of dopaminergic firing patterns, we used single unit extracellular recordings in male F344/N rats. We observed that, with age, the distribution of the spikes fired by dopaminergic neurons shifts from pacemaker to random mode, and then from random to burst mode. These results suggest that the age-dependent changes in the proportion of nigral dopaminergic firing patterns may have an effect on motor function.

Keywords

Aging Electrophysiology F344 rat Firing pattern Substantia nigra pars compacta 

Abbreviations

CV

Coefficient of variation

DA

Dopamine

ECG

Electrocardiogram

EEG

Electroencephalogram

SNc

Substantia nigra pars compacta

Str

Neostriatum

Notes

Acknowledgments

The authors thank Ms. Fulva Shah and Dr. James Tepper for technical advice and Dr. Christian Lee for comments on the manuscript. This work was supported by Research Grants for Longevity Sciences (10C-03) from the Ministry of Health, Labour and Welfare of Japan.

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Copyright information

© Springer-Verlag/Wien Printed in Germany 2009

Authors and Affiliations

  • Yoshiyuki Ishida
    • 1
    • 2
    Email author
  • Tatsuya Kozaki
    • 3
  • Yoshikazu Isomura
    • 4
  • Sachiko Ito
    • 3
  • Ken-ichi Isobe
    • 2
    • 3
  1. 1.Radioisotope Research CenterNagoya University Graduate School of MedicineAichiJapan
  2. 2.Department of Mechanism of AgingNational Institute for Longevity SciencesAichiJapan
  3. 3.Department of ImmunologyNagoya University Graduate School of MedicineNagoyaJAPAN
  4. 4.Neural Circuit TheoryRIKEN Brain Science InstituteWako CityJAPAN

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