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Therapeutisches Drug-Monitoring neuerer atypischer Antipsychotika

  • Conference paper
Book cover Schizophrenie — Zukunftsperspektiven in Klinik und Forschung

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Zusammenfassung

Die Bestimmung der Blutspiegel von Medikamenten spielt eine wichtige Rolle bei der überwachung und Optimierung der medikamentösen Therapie. Verschiedene Einflussfaktoren können die Blutspiegel der Wirkstoffe und ihrer pharmakologisch aktiven Metabolite deutlich beeinflussen. Neben einer unregelmäßigen Einnahme der Medikamente spielt hier der veränderte Abbau der Medikamente (v.a. in der Leber) durch genetische Disposition eine wichtige Rolle. Der Abbau der Medikamente kann zudem durch Komedikation oder andere äußere Einflussfaktoren wie Rauchen deutlich beeinflusst werden. Insgesamt sollte TDM spätestens dann durchgeführt werden, wenn trotz ausreichender Dosierung die erwünschte Wirkung ausbleibt, oder wenn schon bei üblicher Dosierung unerwünschte Arzneimittelwirkungen auftreten.

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Authors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Klinikum der Universität München, Nußbaumstraße 7, 80336, München, Deutschland

    Markus J. Schwarz, R. Musil, I. Spellmann, M. Opgen-Rhein, F. Jurgeleit, S. Sirch, S. Sterz, J. Zach & M. Riedel

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  1. Markus J. Schwarz
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  2. R. Musil
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  3. I. Spellmann
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  4. M. Opgen-Rhein
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  5. F. Jurgeleit
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  6. S. Sirch
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  7. S. Sterz
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  8. J. Zach
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  9. M. Riedel
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Corresponding author

Correspondence to Markus J. Schwarz .

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Editors and Affiliations

  1. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Ludwig-Maximilians-Universität München, Nußbaumstraße 7, 80336, München, Deutschland

    H.-J. Möller  & N. Müller  & 

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Schwarz, M.J. et al. (2010). Therapeutisches Drug-Monitoring neuerer atypischer Antipsychotika. In: Möller, HJ., Müller, N. (eds) Schizophrenie — Zukunftsperspektiven in Klinik und Forschung. Springer, Vienna. https://doi.org/10.1007/978-3-211-92215-6_18

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  • DOI: https://doi.org/10.1007/978-3-211-92215-6_18

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-92214-9

  • Online ISBN: 978-3-211-92215-6

  • eBook Packages: Medicine (German Language)

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