Background Cerebral cortical expression of the pituitary hormones prolactin (PRL) and growth hormone (GH) have reported in ischemic damage. Both hormones may be involved in vascular tone regulation and angiogenesis, and growth hormone is thought to be neuroprotective while prolactin stimulates astrogliosis.
Methods We examined expression of prolactin, growth hormone and adrenocorticotrophic hormone (ACTH) using tissue microarray technology in the controlled cortical impact model of traumatic brain injury (TBI).
Findings No increased expression of these hormones was seen.
Conclusions Unlike ischemia, traumatic brain injury does not result in up-regulation of the pituitary hormones PRL and GH in cerebral cortex.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Cherian L, Chacko G, Goodman C, Robertson CS (2003) Neuro-protective effects of L-arginine administration after cortical impact injury in rats: dose response and time window. J Pharmacol Exp Ther 304:(2)617–623
Clapp C et al (2006) Vasoinhibins: endogenous regulators of angiogenesis and vascular function. Trends Endocrinol Metab 17 (8):301–307
Clapp C, Gonzalez C, Macotela Y, Aranda J, Rivera JC, Garcia C, Guzman J, Zamorano M, Vega C, Martin C, Jeziorski MC, de la Escalera GM (2006) Vasoinhibins: a family of N-terminal prolactin fragments that inhibit angiogenesis and vascular function. Front Horm Res 35:64–73
Moderscheim TA et al (2007) Prolactin is involved in glial responses following a focal injury to the juvenile rat brain. Neuroscience 145(3):963–973
Scheepens A et al (2001) Growth hormone as a neuronal rescue factor during recovery from CNS injury. Neuroscience 104(3):677–687
Wang H, Wang H, Zhang W, Fuller GN (2002) Tissue microarrays: applications in neuropathology research, diagnosis, and education. Brain Pathol 12(1):95–107
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2008 Springer-Verlag/Wien
About this paper
Cite this paper
Goodman, J.C., Cherian, L., Robertson, C.S. (2008). Cortical expression of prolactin (PRL), growth hormone (GH) and adrenocorticotrophic hormone (ACTH) is not increased in experimental traumatic brain injury. In: Steiger, H.J. (eds) Acta Neurochirurgica Supplements. Acta Neurochirurgica Supplementum, vol 102. Springer, Vienna. https://doi.org/10.1007/978-3-211-85578-2_75
Download citation
DOI: https://doi.org/10.1007/978-3-211-85578-2_75
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-85577-5
Online ISBN: 978-3-211-85578-2
eBook Packages: MedicineMedicine (R0)