Background Traumatic subarachnoid hemorrhage is a common finding following traumatic brain injury. Clinical studies revealed a positive influence of Nimodipine. However, till now no experimental studies have been performed. The aim of the present study was to determine the influence of early Nimodipine administration on outcome and histological findings in the rat
Methods Diffuse brain injury was produced in Sprague-Dawley rats using a brass weight falling from a predetermined height. Traumatic subarachnoidal hemorrhage was produced by administration of heparin before the injury. A total number of 52 animals were divided in 4 groups.
Findings Mortality increased following administration of heparin. Mortality was not reduced following administration of Nimodipine. The histological investigation revealed less cell loss in animals with administration of Nimodipine as well as increased GFAP immunoexpression.
Conclusions Administration of Heparin results in a marked traumatic subrachnoidal hemorrhage following diffuse traumatic brain injury. Administration of Nimodipine does not reduce overall mortality. However, histological investigations indicate a positive effect of Nimodipine on cell loss.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Eisenberg HM, Gary HE, Aldrich EF et al (1990) Initial CT findings in 753 patients with severe head injury. A report from the NIH Traumatic Coma Data Bank. J Neurosurg 73:688–698
European study group on Nimodipine in severe head injury (1994) A multicenter trial of the efficacy of Nimodipine on outcome after severe head injury. J Neurosurg 80:797–804
Marmarou A, Foda MAA, Van den Brink W, Campbell J, Kita H, Demetriadou K (1994) A new model of diffuse brain injury in rats. Part I: Pathophysiology and biomechanics. J Neurosurg 80:291–300
Kakarieka A, Braakman R, Schakel EH (1994) Clinical significance of the finding of subarachnoidal blood on CT scan after head injury. Acta Neurochir 129:1–5
Kakarieka A (1997) Traumatic subarachnoidal haemorrhage. Springer, Berlin, Heidelberg, New York, p 21
Kobayashi S, Nakazawa S, Hiroyuki Y et al (1988) Traumatic subarachnoid hemorrhage in acute severe head injury. No To Shinkei 40:1131–1135
Lee JH, Martin NA, Alsina G, McArthur DL, Zaucha K, Hovda DA, Becker DP (1997) Hemodynamically significant cerebral vasospasm and outcome after head injury: A prospective study. J Neurosurg 87:221–233
Servadei F, Murray GD, Teasdale GM, Dearden M et al (2002) Traumatic subarachnoid hemorrhage: Demographic and clinical study of 750 patients from the European Brain Injury Consortium survey of Head Injuries. Neurosurgery 50:261–269
Thomas S, Tabibinia F, Herrmann B, Schuhmann MU, Brinker T, Samii M (1999) Traumatic subarachnoidal hemorrhage: Introduction of a new experimental model in the rat. J Neurotrauma 16:959
Thomas S, Tabibnia F, Schuhmann MU, Brinker T, Samii M (2000) ICP and MABP following traumatic subarachnoidal hemorrhage in the rat. Acta Neurochir (Suppl) 76:203–205
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2008 Springer-Verlag/Wien
About this paper
Cite this paper
Thomas, S., Herrmann, B., Samii, M., Brinker, T. (2008). Experimental subarachnoid hemorrhage in the rat: influences of nimodipine. In: Steiger, H.J. (eds) Acta Neurochirurgica Supplements. Acta Neurochirurgica Supplementum, vol 102. Springer, Vienna. https://doi.org/10.1007/978-3-211-85578-2_72
Download citation
DOI: https://doi.org/10.1007/978-3-211-85578-2_72
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-85577-5
Online ISBN: 978-3-211-85578-2
eBook Packages: MedicineMedicine (R0)