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Pre-vasospasm: early brain injury

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Book cover Cerebral Vasospasm

Part of the book series: Acta Neurochirurgica Supplement ((NEUROCHIRURGICA,volume 104))

Abstract

Despite modern advances in surgery, subarachnoid haemorrhage (SAH) continues to carry high morbidity and mortality rates. The reasons for this are currently unclear. It is certain however that vasospasm is not the only modality responsible for this. As a result the concept of Early Brain Injury (EBI) has been introduced in an effort to focus attention on other aspects of SAH. EBI occurs within the first 72 h after a SAH and encompasses the complex pathophysiological events that occur in the brain at the moment of a SAH and shortly thereafter. It has been hypothesised that these events may be responsible for many of the long term consequences of SAH that have to date remained poorly understood. The key component of EBI is apoptosis, evidence of which has been previously noted on autopsy studies. Detailed knowledge of the apoptotic pathways in relation to SAH may provide useful therapeutic options for the treatment of patients with SAH in the future.

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Author information

Authors and Affiliations

  1. Department of Physiology, Loma Linda University Medical School, Loma Linda, California, USA

    J. Cahill & John H. Zhang MD, PhD

  2. Division of Neurosurgery, Loma Linda University Medical Centre, 11234 Anderson Street, Room 2562B, Loma Linda, California, 92354, USA

    John H. Zhang MD, PhD

Authors
  1. J. Cahill
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  2. John H. Zhang MD, PhD
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Corresponding author

Correspondence to John H. Zhang MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Medical Faculty of Istanbul, University of Istanbul, Istanbul, Turkey

    Talat Kırış

  2. Department of Neurosurgery, Loma Linda University Medical Center, Loma Linda, USA

    John H. Zhang

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© 2008 Springer-Verlag

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Cahill, J., Zhang, J.H. (2008). Pre-vasospasm: early brain injury. In: Kırış, T., Zhang, J.H. (eds) Cerebral Vasospasm. Acta Neurochirurgica Supplement, vol 104. Springer, Vienna. https://doi.org/10.1007/978-3-211-75718-5_2

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  • DOI: https://doi.org/10.1007/978-3-211-75718-5_2

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  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-75717-8

  • Online ISBN: 978-3-211-75718-5

  • eBook Packages: MedicineMedicine (R0)

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