Abstract
A key mechanism of gene regulation involves the binding of transcription factors to the promoter regions of their respective target genes. This mechanism has long been studied for individual promoters and specific transcription factors using a number of experimental techniques, such as DNAse footprinting (Galas and Schmitz 1978), gel-shift assays (Fried and Crothers 1981) and SELEX (Tuerk and Gold 1990).
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Manke, T., Roider, H., Vingron, M. (2008). A biophysical approach to large-scale protein-DNA binding data. In: Frishman, D., Valencia, A. (eds) Modern Genome Annotation. Springer, Vienna. https://doi.org/10.1007/978-3-211-75123-7_5
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DOI: https://doi.org/10.1007/978-3-211-75123-7_5
Publisher Name: Springer, Vienna
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