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Therapeutic drug monitoring of antidepressants — clinical aspects

  • Conference paper
Neuropsychiatric Disorders An Integrative Approach

Part of the book series: Journal of Neural Transmission. Supplementa ((NEURALTRANS,volume 72))

Abstract

Therapeutic Drag Monitoring (TDM) is a tool to optimise antidepressant pharmacotherapy improving efficacy and avoiding side effects. The Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)-TDM group has worked out consensus guidelines to make progress in the use of TDM which in spite of its obvious advantages, is far from optimal in everyday clinical practice. Research-based levels of recommendation were defined with regard to routine monitoring of plasma concentrations for dose titration. Main indications of TDM compromise control of compliance, lack of clinical response or adverse effects at recommended doses, drag interactions, pharmacovigilance programs, presence of a genetic predisposition particularity concerning the drug metabolism, children, adolescents and elderly patients. Therapeutic ranges of plasma concentrations that are considered to be optimal for treatment are proposed, implications on pharmacoeconomics aspects are discussed. The need to improve the implementation of TDM in routine patient care is emphasized.

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Author information

Authors and Affiliations

  1. Hospital and Clinic for Psychiatry, Psychotherapy, Psychosomatic Medicine and Neurology, Academic Hospital Ludwig-Maximilians University Munich, Gabersee 7, 83512, Wasserburg a. Inn, Germany

    Prof. Dr. G. Laux

  2. Inn-Salzach-Klinikum, Hospital and Clinic for Psychiatry, Psychotherapy, Psychosomatic Medicine and Neurology, Academic Hospital Ludwig-Maximilians University Munich, Gabersee 7, 83512, Wasserburg a. Inn, Germany

    Prof. Dr. G. Laux

  3. Inn-Salzach-Klinikum, Wasserburg a. Inn, Germany

    P. Baumann

  4. Department of Psychiatry, University of Lausanne, Prilly-Lausanne, Switzerland

    C. Hiemke

Authors
  1. Prof. Dr. G. Laux
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  2. P. Baumann
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  3. C. Hiemke
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  4. Bergemann N Heidelberg
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  5. Deckert J Würzburg
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  6. Dobmeier M Cham
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  7. Eckermann G Kaufbeuren
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  8. Gerlach M Würzburg
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  9. Haen E Regensburg
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  10. Jaquenoud-Sirot E Königsfelden
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  11. Köhnke M Rostock
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  12. Kuss HJ München
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  13. Messer T Augsburg
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  14. Pfuhlmann B Würzburg
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  15. Rao ML Bonn
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  16. Schoppek B Haar
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  17. Schwarz M München
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Consortia

The TDM group of the Arbeitsgemeinschaft Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Kinder- und Jugendpsychiatrie und Psychotherapie, Würzburg, Germany

    M. Gerlach

  2. Klinik und Poliklinik für Psychiatrie und Psychotherapie, Würzburg, Germany

    Jürgen Deckert

  3. Prince of Wales Medical Research Institute, Sydney, Australia

    K. Double

  4. Institut für Virologie und Immunobiologie, Würzburg, Germany

    E. Koutsilieri

Additional information

Dedicated to Peter Riederer as memory for 7 years working together at Wuerzburg and more than 20 years of friendship.

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© 2007 Springer-Verlag

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Laux, G. et al. (2007). Therapeutic drug monitoring of antidepressants — clinical aspects. In: Gerlach, M., Deckert, J., Double, K., Koutsilieri, E. (eds) Neuropsychiatric Disorders An Integrative Approach. Journal of Neural Transmission. Supplementa, vol 72. Springer, Vienna. https://doi.org/10.1007/978-3-211-73574-9_32

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  • DOI: https://doi.org/10.1007/978-3-211-73574-9_32

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-73573-2

  • Online ISBN: 978-3-211-73574-9

  • eBook Packages: MedicineMedicine (R0)

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