Abstract
The term cutis tricolor describes the combination of congenital hyper- and hypopigmented lesions (in the form of macules, patches or streaks), in close proximity to each other, in a background of normal skin (Baba et al. 2003; Happle 2006; Happle et al. 1997; Khumalo et al. 2001; Ruggieri 2000; Ruggieri et al. 2003, 2000, Seraslan and Atik 2005) This phenomenon has been reported either as an isolated skin disorder (Baba et al. 2003, Khumalo et al. 2001, Ruggieri 2000, Seraslan and Atik 2005) or as a part of a neurocutaneous malformation syndrome (Cutis tricolor syndrome or Ruggieri-Happle syndrome) (POSSUM 2006) in association with multiple congenital anomalies, including facial anomalies, cortical cataract (Ruggieri et al. 2008) neurological (mild hypotonia, mild to moderate mental retardation, epilepsy and EEG abnormalities) and behavioural abnormalities and specific skeletal defects consisting in skull, vertebral and long bones dysplasia (Happle et al. 1997; Ruggieri 2000; Ruggieri et al. 2003, 2008).
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Ruggieri, M., Roggini, M., Kennerknecht, I., Schepis, C., Iannetti, P. (2008). Cutis Tricolor (Ruggieri-Happle Syndrome). In: Ruggieri, M., Pascual-Castroviejo, I., Di Rocco, C. (eds) Neurocutaneous Disorders Phakomatoses and Hamartoneoplastic Syndromes. Springer, Vienna. https://doi.org/10.1007/978-3-211-69500-5_25
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