Summary
Brain expression of cytochromes P450 2B6, 2D6 and 2E1 is higher in smokers, and is induced by nicotine in animals. These enzymes can metabolize many of the neurotoxins associated with Parkinson’s disease. Since smoking is known to be protective against Parkinson’s disease, we hypothesise that nicotine-induced elevation of brain CYPs in smokers may contribute to neuroprotection against Parkinson’s disease. This supports the therapeutic use of nicotine to delay the progress of this disease.
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References
Elbaz A, Levecque C, Clavel J, Vidal JS, Richard F, Amouyel P, Alperovitch A, Chartier-Harlin MC, Tzourio C (2004) CYP2D6 polymorphism, pesticide exposure, and Parkinson’s disease. Ann Neurol 55: 430–434
Howard LA, Miksys S, Hoffmann E, Mash D, Tyndale RF (2003) Brain CYP2E1 is induced by nicotine and ethanol in rat and is higher in smokers and alcoholics. Br J Pharmacol 138: 1376–1386
McCann SJ, Pond SM, James KM, Le Couteur DG (1997) The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson’s disease: a case-control study and meta-analysis. J Neurol Sci 153: 50–53
Miksys S, Tyndale RF (2004) The unique regulation of brain cytochrome P450 2 (CYP2) family enzymes by drugs and genetics. Drug Metab Rev 36: 313–333
Miksys S, Hoffmann E, Tyndale RF (2000) Regional and Cellular Induction of Nicotine-Metabolizing CYP2B1 in Rat Brain by Chronic Nicotine Treatment. Biochem Pharmacol 59: 1501–1511
Miksys S, Rao Y, Hoffmann E, Mash DC, Tyndale RF (2002) Regional and cellular expression of CYP2D6 in human brain: higher levels in alcoholics. J Neurochem 82: 1376–1387
Miksys S, Lerman C, Shields PG, Mash DC, Tyndale RF (2003) Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain. Neuropharmacology 45: 122–132
Miksys SL, Tyndale RF (2002) Drug-metabolizing cytochrome P450s in the brain. J Psychiatry Neurosci 27: 406–415
Quik M (2004) Smoking, nicotine and Parkinson’s disease. Trends Neurosci 27: 561–568
Vaglini F, Pardini C, Viaggi C, Bartoli C, Dinucci D, Corsini GU (2004) Involvement of cytochrome P450 2E1 in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson’s disease. J Neurochem 91: 285–298
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© 2006 Springer-Verlag
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Miksys, S., Tyndale, R.F. (2006). Nicotine induces brain CYP enzymes: relevance to Parkinson’s disease. In: Riederer, P., Reichmann, H., Youdim, M.B.H., Gerlach, M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna . https://doi.org/10.1007/978-3-211-45295-0_28
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DOI: https://doi.org/10.1007/978-3-211-45295-0_28
Publisher Name: Springer, Vienna
Print ISBN: 978-3-211-28927-3
Online ISBN: 978-3-211-45295-0
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