Skip to main content

Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?

  • Conference paper

Part of the Journal of Neural Transmission. Supplementa book series (volume 70)

Summary

An abnormally frequent atypical levodopa-unresponsive, akinetic-rigid syndrome with some similarity to PSP was identified in the Caribbean island Guadeloupe, and was associated with the consumption of plants of the Annonacea family, especially Annona muricata (corossol, soursop) suggesting a possible toxic etiology. Annonaceae contain two groups of potential toxins, alkaloids and acetogenins. Both alkaloids and annonacin, the most abundant acetogenin, were toxic in vitro to dopaminergic and other neurons. However we have focused our work on annonacin for two reasons: (1) annonacin was toxic in nanomolar concentrations, whereas micromolar concentrations of the alkaloids were needed, (2) acetogenins are potent mitochondrial poisons, like other parkinsonism-inducing compounds. We have also shown that high concentrations of annonacin are present in the fruit or aqueous extracts of the leaves of A. muricata, can cross the blood brain barrier since it was detected in brain parenchyma of rats treated chronically with the molecule, and induced neurodegeneration of basal ganglia in these animals, similar to that observed in atypical parkinsonism. These studies reinforce the concept that consumption of Annonaceae may contribute to the pathogenesis of atypical parkinsonism in Guadeloupe.

Keywords

  • Tyrosine Hydroxylase
  • Dopaminergic Neuron
  • Fatty Acid Derivative
  • Ventral Mesencephalon
  • Atypical Parkinsonism

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

This is a preview of subscription content, access via your institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • DOI: 10.1007/978-3-211-45295-0_24
  • Chapter length: 5 pages
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
eBook
USD   269.00
Price excludes VAT (USA)
  • ISBN: 978-3-211-45295-0
  • Instant PDF download
  • Readable on all devices
  • Own it forever
  • Exclusive offer for individuals only
  • Tax calculation will be finalised during checkout
Hardcover Book
USD   349.99
Price excludes VAT (USA)

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Angibaud G, Gaultier C, Rascol O (2004) Atypical parkinsonism and Annonaceae consumption in New Caledonia. Mov Disord 19: 603–604

    PubMed  CrossRef  Google Scholar 

  • Betarbet R, Sherer TB, MacKenzie G, Garcia-Osuna M, Panov AV, Greenamyre JT (2000) Chronic systemic pesticide exposure reproduces features of Parkinson’s disease. Nat Neurosci 3:1301–1006

    PubMed  CAS  CrossRef  Google Scholar 

  • Caparros-Lefebvre D, Elbaz A and the Carribean Parkinsonism Study Group (1999) Possible relation of atypical parkinsonism in the French West Indies with consumption of tropical plants: a case control study. Lancet 354: 281–286

    PubMed  CAS  CrossRef  Google Scholar 

  • Caparros-Lefebvre D, Sergeant N, Lees A, Camuzat A, Daniel S, Lannuzel A, Brice A, Tolosa E, Delacourte A, Duyckaerts C (2002) Guadeloupean Parkinsonism: a cluster of progressive supranuclear palsy-like taupathy. Brain 125: 801–811

    PubMed  CrossRef  Google Scholar 

  • Champy P, Höglinger G, Feger J, Gleye C, Hocquemiller R, Laurens A, Guérineau V, Laprévote O, Medja F, Lombès A, Michel PP, Lannuzel A, Hirsch E, Ruberg M (2004) Acetogenin a lipophilic inhibitor of mitochondrial complex I, induces nigral and striatal neurodegeneration in rats: possible relevance for atypical Parkinsonism in Guadeloupe. J Neurochem 88:63–69

    PubMed  CAS  CrossRef  Google Scholar 

  • Champy P, Melot A, Guérineau V, Gleye C, Fall D, Höglinger G, Ruberg M, Lannuzel A, Laprévote O, Laurens A, Hocquemiller R (2005) Quantification of acetogenins in Annona muricata linked to atypical parkinsonism in Guadeloupe. Mov Disord 20: 1629–1633

    PubMed  CrossRef  Google Scholar 

  • Hoglinger GU, Michel PP, Champy P, Feger J, Hirsch EC, Ruberg M, Lannuzel A (2005) Experimental evidence for a toxic etiology of tropical parkinsonism. Mov Disord 20: 118–119

    PubMed  CrossRef  Google Scholar 

  • Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46:598–605

    PubMed  CAS  CrossRef  Google Scholar 

  • Lannuzel A, Michel PP, Caparros-Lefebvre D, Abaul J, Hocquemiller R, Ruberg M (2002) Toxicity of Annonaceae for dopaminergic neurons: potential role in atypical parkinsonism in Guadeloupe. Mov Disord 17: 84–90

    PubMed  CrossRef  Google Scholar 

  • Lannuzel A, Michel PP, Höglinger GU, Champy P, Jousset A, Medja F, Lombés A, Darios F, Gleye C, Laurens A, Hocquemiller R, Hirsch EC, Ruberg M (2003) The mitochondrial complex I inhibitor annonacin is toxic to mesencephalic neurons by impairment of energy metabolism. Neuroscience 121: 287–296

    PubMed  CAS  CrossRef  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and Permissions

Copyright information

© 2006 Springer-Verlag

About this paper

Cite this paper

Lannuzel, A., Höglinger, G.U., Champy, P., Michel, P.P., Hirsch, E.C., Ruberg, M. (2006). Is atypical parkinsonism in the Caribbean caused by the consumption of Annonacae?. In: Riederer, P., Reichmann, H., Youdim, M.B.H., Gerlach, M. (eds) Parkinson’s Disease and Related Disorders. Journal of Neural Transmission. Supplementa, vol 70. Springer, Vienna . https://doi.org/10.1007/978-3-211-45295-0_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-211-45295-0_24

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-211-28927-3

  • Online ISBN: 978-3-211-45295-0

  • eBook Packages: MedicineMedicine (R0)