Abstract
Neurosurgical treatment for psychiatric disorders has a long and controversial history dating back to antiquity. Both enthusiastic reports and social outcry have accompanied psychosurgical practice, particularly over the last century. Frontal lobotomy has probably been the only medical advance which was first awarded a Nobel prize in medicine and then irreparably stigmatized by scientific rejection and public criticism. In the present paper, the historical milestones of psychosurgery are briefly overviewed. The particular circumstances of the rise and fall of frontal lobotomy are also discussed. Furthermore, the clinical and surgical considerations of the four major psychosurgical procedures which are still in practice are presented.
Over the last fifteen years, the advent of deep brain stimulation (DBS) methodology coupled with accurate stereotactic techniques and guided by elaborate neuroimaging methods have revolutionized neurosurgery, particularly for the alleviation of certain disabling movement disorders. Investigationally, chronic electrical stimulation of selected brain structures, clearly implicated in the pathophysiology of neuropsychiatric disorders, has already been applied with promising results. Given the tainted past of psychiatric neurosurgery, modern neuroscientists have to move forward cautiously, in a scientifically justified and ethically approved framework. The transition from the indiscriminate destruction of brain structures to the selected electrical modulation of neural networks lies ahead; contemporary neuroscientists would substantiate this aim but should remind the controversial history of the field.
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References
Abelson JL, Curtis GC, Sagher O et al (2005) Deep brain stimulation for refractory obsessive-compulsive disorder. Biol Psychiatry 57: 510–516
Alt KW, Jeunesse C, Buitrago-Tellez CH et al (1997) Evidence for stone age cranial surgery. Nature 387: 360
American Psychiatric Association (1994) Dignostic and statistical manual of mental disorders, ed. 4. American Psychiatric Association, Washington, DC
Anderson D, Ahmed A (2003) Treatment of patients with intractable obsessive-compulsive disorder with anterior capsular stimulation. J Neurosurg 98: 1104–1108
Aouizerate B, Cuny E, Maritn-Guehl C, Guehl D et al (2004) Deep brain stimulation of the ventral caudate nucleus in the treatment of obsessive-compulsive disorder and major depression. J Neurosurg 101: 682–686
Baer L, Rauch SL, Ballantine HT Jr et al (1995) Cingulotomy for intractable obsessive-compulsive disorder: prospective long-term follow-up of 18 patients. Arch Gen Psychiatry 52: 384–392
Barraclough GM, Mitchell-Heggs NA (1978) The use of psychosurgery for psychological disorders in the British Isles during 1974–1976. BMJ 2: 1591–1593
Benabid AL, Pollak P, Gervason C et al (1991) Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus. Lancet 337: 403–406
Binder DK, Iskandar BJ (2000) Modern neurosurgery for psychiatric disorders. Neurosurgery 47: 9–23
Bouckoms AJ (1988) Ethics of psychosurgery. Acta Neurochir Suppl 44: 173–178
Breit S, Schulz JB, Benabid AL (2004) Deep brain stimulation. Cell Tissue Res 318: 275–288
Broca P (1865) Sur le liege de la faculte du language articule. Bull Soc Anthropol 377–393
Broca P (1878) Anatomie comparée circonvolutions cérébrales: le grand lobe limbique et la scissure limbique dans la série des mammiferes. Rev Anthropol 1: 385–498
Burckhardt G (1891) Über Rindenexcisionen als Beitrag zur operativen Therapie der Psychosen. Allg Z Psychiatr Psych Med 47: 463–548
Cosgrove GR, Rauch SL (1995) Psychosurgery. Neurosurg Clin N Am 6: 167–176
Cosgrove GR, Rauch SL (2003) Stereotactic cingulotomy. Neurosurg Clin N Am 14: 225–235
Culliton BJ (1976) Psychosurgery: national commission issues surprisingly favourable report. Science 194: 299–301
Dougherty DD, Baer L, Cosgrove GR et al (2002) Prospective long-term follow-up of 44 patients who received cingulotomy for treatment-refractory obsessive-compulsive disorder. Am J Psychiatry 159: 269–275
Feldman RP, Alterman RL, Goodrich JT (2001) Contemporary psychosurgery and a look to the future. J Neurosurg 95: 944–956
Feldman RP, Goodrich JT (2001) Psychosurgery: a historical overview. Neurosurgery 48: 647–659
Fins JJ (2003) From psychosurgery to neuromodulation and palliation: history’s lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurg Clin N Am 14: 303–319
Freeman W (1948) Transorbital leucotomy. Lancet 2: 371–373
Freeman W, Watts J (1942) Psychosurgery. Charles C. Thomas, Springfield
Fulton JF (1949) Physiology of the nervous system. Oxford University Press, New York
Fulton JF (1951) Frontal lobotomy and affective behavior: a neurophysiological analysis. WW Norton, New York
Goktepe EO, Young LB, Bridges PK et al (1975) A further review of the results of stereotactic subcaudate tractotomy. Br J Psychiatry 126: 270–280
Greenberg BD (2002) Update on deep brain stimulation. J ECT 18: 193–196
Gross RE (2004) Deep brain stimulation in the treatment of neurological and psychiatric disease. Expert Rev Neurotherapeutics 4(3): 465–478
Hariz M (2002) Complications of deep brain stimulation. Mov Disord 17Suppl 3: S162–S166
Hay P, Sachdev P, Cumming S et al (1993) Treatment of obsessivecompulsive disorder by psychosurgery. Acta Psychiatr Scand 87: 197–207
Insel TR (1992) Toward a neuroanatomy of obsessive-compulsive disorder. Arch Gen Psychiatry 49: 739–744
Jacobsen CF (1935) Functions of frontal association area in primates. Arch Neurol Psychiatry 33: 558–569
Jenike MA (1998) Neurosurgical treatment of obsessive-compulsive disorder. Br J Psychiatry Suppl 35: 79–90
Jenike MA, Baer L, Ballantine T et al (1991) Cingulotomy for refractory obsessive-compulsive disorder: a long-term follow-up of 33 patients. Arch J Psychiatry 48: 548–555
Jimenez F, Velasco F, Salin-Pascual R et al (2005) A patient with resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle. Neurosurgery 57: 585–593
Kelly D, Richardson A, Mitechell-Heggs N et al (1973) Sterotactic limbic leucotomy: a preliminary report on forty patients. Br J Psychiatry 123: 141–148
Knight GC (1964) The orbital cortex as an objective in the surgical treatment of mental illness. The development of the stereotactic approach. Br J Surg 51: 114–124
Kopell BH, Greenberg B, Rezai AR (2004) Deep brain stimulation for psychiatric disorders. J Clin Neurophysiol 21: 51–67
Leksell L (1971) Stereotaxis and radiosurgery. Springfield IL, Thomas
MacLean PD (1952) Some psychiatric implications of physiological studies on the frontotemporal portion of the limbic system (visceral brain). Electroencephalogr Clin Neurophysiol 4: 407–418
MacLean PD (1955) The limbic system (“visceral brain”) and emotional behaviour. Arch Neurol Psychiatry 73: 130–134
Mark VH, Ervin FR (1970) Violence and the brain. Harper and Row, New York
Mashour GA, Walker EE, Martuza RL (2005) Psychosurgery: past, present, and future. Brain Res Rev 48: 409–419
Mayberg HS, Lozano AM, Voon V et al (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45: 651–660
Mayberg HS, Starkstein SE, Peyser CE et al (1992) Paralimbic frontal lobe hypometabolism in depression associated with Huntington’s disease. Neurology 42: 1791–1797
Meyerson BA (1998) Neurosurgical treatment of mental disorders: introduction and indications. In: Gildenberg PL, Tasker RR (eds) Textbook of stereotactic and functional neurosurgery. McGraw-Hill, USA, pp 1955–1964
Mindus P (1993) Present-day indications for capsulotomy. Acta Neurochir Suppl 58: 29–33
Mindus P, Bengstrom K, Levander SE et al (1987) Magnetic resonance images related to clinical outcome after psychosurgical intervention in severe anxiety disorder. J Neurol Neurosurg Psychiatry 50: 1288–1293
Mindus P, Rasmussen SA, Lindquist C (1994) Neurosurgical treatment for refractory obsessive-compulsive disorder: implications for understanding frontal lobe function. J Neuropsychiatry 6: 467–477
Moniz E (1936) Essai d’ un traitement chirurgical de certaine psychoses. Bull Acad Med 115: 385–393
Moniz E (1937) Prefrontal leucotomy in the treatment of mental disorders. Am J Psychiatry 93: 1379–1385
National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research (1977) Use of psychosurgery in practice and research: report and recommendations of National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. Fed Regist 42: 26318–26332
Nuttin B, Cosyns P, Demeulemeester H, Gybels J, Meyerson B (1999) Electrical stimulation in anterior limbs of internal capsules in patients with obsessive-compulsive disorder. Lancet 354: 1526
Nuttin BJ, Gabriels LA, Cosyns PR, Meyerson BA et al (2003) Long-term electrical capsular stimulation in patients with obsessive-compulsive disorder. Neurosurgery 52: 1263–1274
Nuttin B, Gybels J, Cosyns P et al (2002) OCD-DBS collaborative group. Deep Brain Stimulation for Psychiatric Disorders
Nuttin B, Gybels J, Cosyns P et al (2003) Deep brain stimulation for psychiatric disorders. Clin N Am 14: xv–xvi
Papez JW (1937) A proposed mechanism of emotion. Arch Neurol Psychiatry 38: 725–737
Pippard J (1962) Leucotomy in Britain today. J Ment Sci 108: 249–255
Pool JL (1954) Psychosurgery in older people. J Am Geriatr Soc 2: 456–465
Robinson D, Wu H, Munne LA et al (1995) Reduced caudate volume in obsessive compulsive disorder. Arch Gen Psychiatry 52: 393–398
Sakas DE, Panourias IG (2006) Rostral cingulate gyrus: A putative target for deep brain stimulation in treatment-refractory depression. Med Hypotheses 66(3): 491–494
Saxena S, Brody AL, Maidment KM et al (1999) Localized orbitofrontal and subcortical metabolic changes and predictors or response to paroxetine treatment. I: obsessive-compulsive disorder. Neuropsychopharmacology 21: 683–693
Scarone S, Colombo C, Livian S et al (1992) Increased right caudate nucleus size in obsessive-compulsive disorder: detection and magnetic resonance imaging. Psychiatry Res 45: 115–121
Schlaepfer T, Lieb K (2005) Deep brain stimulation for the treatment of refractory depression. Lancet 366: 1420–1422
Seminowicz DA, Mayberg HS, McIntosh AR, Goldapple K, Kennedy S, Segal Z et al (2004) Limbic-frontal circuitry in major depression: a path modeling metanalysis. Neuroimage 22: 409–418
Spiegel EA, Wycis HT, Marks M, Lee ASJ (1947) Sterotaxic apparatus for operations on the human brain. Science 106: 349–350
Sprangler WJ, Cosgrove GR, Ballantine HT Jr et al (1996) Magnetic resonance image-guided stereotactic cingulotomy for intractable psychiatric disease. Neurosurgery 38: 1071–1078
Sturm V, Lenartz D, Koulousakis A, Treuer H et al (2003) The nucleus accumbens: a target for deep brain stimulation in obsessivecompulsive-and anxiety-disorders. J Chem Neuroanat 26: 293–299
Swayze VW (1995) Frontal leucotomy and related psychosurgical procedures in the era before antipsychotics (1935–1954). A historical overview. Am J Psych 152: 505–515
Tooth GC, Newton MP (1961) Leucotomy in England and Wales (1942–1954). Report on public health and medical subjects. HMSO, London, p 104
Valenstein ES (1986) Great and desperate cures, Basic Books, New York
Wernicke C (1874) Der Aphasische Symptomen Complex. Max Cohn & Weigert, Breslau
Willis T (1664) Cerebri anatome. Martyn & Allestry, London
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Sakas, D.E., Panourias, I.G., Singounas, E., Simpson, B.A. (2007). Neurosurgery for psychiatric disorders: from the excision of brain tissue to the chronic electrical stimulation of neural networks. In: Sakas, D.E., Simpson, B.A. (eds) Operative Neuromodulation. Acta Neurochirurgica Supplements, vol 97/2. Springer, Vienna. https://doi.org/10.1007/978-3-211-33081-4_42
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