Bacterial Methionine Gamma-Lyase as a Possible Antitumor Agent

  • T. T. Berezov
Part of the Birkhäuser Congress Reports book series (ALS)


Methionine gamma-lyase exhibits cytotoxic effects towards lines of murine leukemia cells, but not towards human carcinoma ovaris cells and normal human fibroblasts. In the presence of enzyme the complete inhibition of DNA and RNA synthesis was observed within 24 hrs of incubation. The leucemic cells completely lost viability within 24–48 hrs.


Pyridoxal Phosphate Normal Human Fibroblast Enzyme Therapy Human Carcinoma Ovaris Cell Essential Growth 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Berezov, T.T. (1984) Vestnik of USSR Acad.Med.Sci. 8, 11–24Google Scholar
  2. Greenfield, R.S., Wellner, D. (1977) Cancer Re. 37, 2523–2529Google Scholar
  3. Hoffman, R.M., Erbe, R.W. (1976) Proc.Nat.Acad.Sci. 73, 1523–1527Google Scholar
  4. Holcenberg, J.S., Roberts, J. (1977) Ann.Rev.Pharmacol.Toxicol. 17, 97–116Google Scholar
  5. Khaduev, S.Kh., Zhukova, O.S., Dobrinin, Ya.V., Soda, K., Beresov, T.T. (1987) Bull.Expt.Biol.Med. 4, 458–460Google Scholar
  6. Kreis, W. (1979) Cancer Treat.Rep. 63, 1069–1072Google Scholar
  7. Kreis, W., Hession, C. (1973) Cancer Res. 33, 1862–1865Google Scholar
  8. Pekhov, A.A., Zanin, V.A., Kozlov, A.M., Yurchenko, A.Ya., Kondratyeva, N.A., Berezov, T.T. (1986) Bull.Expt.Biol.Med. 7, 71–74Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1987

Authors and Affiliations

  • T. T. Berezov
    • 1
  1. 1.Department of BiochemistryPeople’s Friendship UniversityMoscowUSSR

Personalised recommendations