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Bacterial Methionine Gamma-Lyase as a Possible Antitumor Agent

  • T. T. Berezov
Part of the Birkhäuser Congress Reports book series (ALS)

Summary

Methionine gamma-lyase exhibits cytotoxic effects towards lines of murine leukemia cells, but not towards human carcinoma ovaris cells and normal human fibroblasts. In the presence of enzyme the complete inhibition of DNA and RNA synthesis was observed within 24 hrs of incubation. The leucemic cells completely lost viability within 24–48 hrs.

Keywords

Pyridoxal Phosphate Normal Human Fibroblast Enzyme Therapy Human Carcinoma Ovaris Cell Essential Growth 
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Copyright information

© Birkhäuser Verlag Basel 1987

Authors and Affiliations

  • T. T. Berezov
    • 1
  1. 1.Department of BiochemistryPeople’s Friendship UniversityMoscowUSSR

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