Summary
Recent reports have led to widespread interest in the role of β-nerve growth factor (βNGF) in the central nervous system. To learn more about the action of βNGF in the central nervous system we have mapped the distribution of βNGF receptors and compared it with that of acetylcholinesterase (AChE), a sensitive enzyme marker for cholinergic neurons.
in situ autoradiography revealed strong and saturable βNGF bnding to several groups of neurons in basal forebrain and brainstem. They also contain significant levels of mRNA coding for βNGF receptors. βNGF receptors and AChE are condistributed on the medial septal nuclei and in the basal forebrain, including the striatum. In the brainstem, βNGF receptors are present on the neurons in the lower part of the reticular formation and in cochlear nuclei but do not correspond to the distribution of AChE reactivity.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Björklund, A., and Stenevi, U. (1981) In vivo evidence for a hippocampal neurotrophic factor specifically released after septal deafferentation. Brain Res. 229: 403–428.
Butcher, L. L., and Woolf, N. J. (1984) Histochemical distribution of AChE in the central nervous system: clues to the localization of the cholinergic neurones. In: Björklund, A., Hökfelt, T., and Kuhar, M. J. (eds), Handbook of Chemical Neuroanatomy, Vol. 3. Elsevier, Amsterdam, pp. 1–50.
Collins, F., and Crutcher, K. A. (1985) Neurotrophic activity in the adult rat hyppocampal formation. Regional distribution and increase after septal lesion. J Neurosci. 5: 2809–2814.
Eckenstein, F., and Sofroniew, M. W. (1983) Identification of central cholinergic neurons containing both cholineacetyltransferase and acetylcholinesterase and of central neurons containing only acetylcholinesterase. J. Neurosci. 3: 2286–2291.
Gnahn, H., Hefti, F., Heumann, R., Schwab, M. E., and Thoenen, H. (1983) NGF-mediated increase of choline acetyltransferase (ChAT) in the neonatal forebrain: evidence for a physiological role of bNGF in the brain? Dev. Brain Res. 9: 45–52.
Green, S. H., Rydel, R. E., Connolly, J. L., and Greene, L. A. (1986) PC12 cell mutants that possess low- but not high affinity nerve growth factor receptors neither respond nor internalize nerve growth factor. J. Cell Biol. 102: 830–843.
Hefti, F. (1986) Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transection. J. Neurosci. 6: 2155–2162.
Heumann, R., Korsching, S., Scott, J., and Thoenen, H. (1984) Relationship between the levels of nerve growth factor (NGF) and its messenger mRNA in sympathetic ganglia and peripheral target tissues. EMBO J. 3: 3183–3189.
Honegger, P., and Lenoir, D. (1982) Nerve growth factor (NGF) stimulation of cholinergic telencephalic neurons in aggregating cell cultures. Dev. Brain Res. 3: 229–238.
Korsching, S., Auburger, G., Heumann, R., Scott, J., and Thoenen, H. (1985) Levels of nerve growth factor and its mRNA in the central nervous system correlate with cholinergic innervation. EMBO J. 4: 1389–1394.
Levey, A. I., Wainer, B. H., Mufson, E. J., and Mesulam, M.-M. (1983) Colocalization of acetylcholinesterase and cholineacetyl-transferase in the rat cerebrum. Neuroscience 9: 9–22.
Levi-Montalcini, R., and Angeletti, P. U. (1968) The nerve growth factor. Physiol. Rev. 48: 534–569.
Martinez, H. J., Dreyfus, C. F., Jonakeit, M., and Black, I. B. (1985) Nerve growth factor promotes cholinergic development in brain striatal cultures. Proc. natl Acad. Sci. USA 82: 7777–7781.
Mobley, W. C., Rutkowski, J. L., Tennekoon, G. I., Buchanan, K., and Johnston, M. V. (1985) Choline acetyltransferase activity in the striatum of neonatal rats increased by nerve growth factor. Science 229: 284–287.
Olson, L., Ebendal, T., and Seiger, A. (1979) NGF and anti-NGF: evidence against effects on fiber growth in locus coeruleus from cultures of perinatal CNS cultures. Dev. Neurosci. 2: 160–176.
Pioro, E. P., and Cuello, A. C. (1988) Purkinje cells of adult cerebellum express nerve growth factor receptor immunoreactivity: light microscopical observations. Brain Res. 455: 182– 186.
Raivich, G., and Kreutzberg, G. W. (1987) The localization and distribution of high affinity P-nerve growth factor binding sites of the adult rat. A light microscopic autoradiographic study using (125I) β-nerve growth factor. Neuroscience 20: 23–36.
Raivich, G., Zimmermann, A., and Sutter, A. (1985) The spatial and temporal pattern of pNGF receptor expression in the developing chick embryo. EMBO J. 4: 637–644.
Raivich, G., Zimmermann, A., and Sutter, A. (1987) Nerve growth factor receptor expression in chicken cranial development J. comp. Neurol. 256: 229–245.
Richardson, P. M., Verge Issa, V. M. K., and Riopelle, R. J. (1986) Distribution of neuronal receptors for nerve growth factor in the rat. J. Neurosci. 6: 2312–2321.
Riopelle, R. J., Verge Issa, V. M. K., and Richardson, P. M. (1987) Properties of receptors for nerve growth factor in the mature rat nervous system. Molec. Brain Res. 3: 45–53.
Schwab, M. E., Otten, U., Agid, Y., and Thoenen, H. (1979) Nerve growth factor (NGF) in the rat CNS: absence of specific retrograde transport and tyrosine hydroxylase induction in locus coeruleus and substantia nigra. Brain Res. 168: 473–483.
Schechter, A. L., and Bothwell, M. A. (1981) Nerve growth factor receptors on PC 12 cells. Evidence for two receptor classes with differing cytoskeletal associated characteristics. Cell 24: 867–874.
Seiler, M., and Schwab, M. E. (1984) Specific retrograde transport of nerve growth factor from the neocortex to nucleus basalis in the rat. Brain Res. 300: 33–39.
Shelton, D. L., and Reichard, L. F. (1986) Studies on the expression of the p-nerve growth factor (NGF) gene in the central nervous system: level and regional distribution of NGF mRNA suggest that NGF functions as a trophic factor for several distinct populations of neurons. Proc. natl Acad. Sci. USA 83: 2714–2718.
Springer, J. E., Koh, S., Tayrien, M. W., and Loy, R. (1987) Basal forebrain magnocellular neurons stain for nerve growth factor receptor: correlation with cholinergic cell bodies and effects of axotomy. J. Neurosci. Res. 17: 111–118.
Sutter, A., Riopelle, R. J., Harris-Warrick, R. M., and Shooter, E. M. (1979) Nerve growth factor receptors: characterization of two distinct classes of binding sites on the chick embryo sensory ganglia cells. J. biol. Chem. 254: 5972–5982.
Taniuchi, M., Schweitzer, J. B., and Johnson, E. M. (1986) Nerve growth factor molecules in rat brain. Proc. natl Acad. Sci. USA 83: 1950–1954.
Thoenen, H., and Barde, Y. A. (1980) Physiology of nerve growth factor. Physiol. Rev. 60: 1284–1335.
Zimmermann, A., and Sutter, A. (1983) Nerve growth factor (NGF) receptors on glial cells. Cell-cell interaction between neurons and Schwann cells in cultures of chick sensory ganglia. EMBO J. 2: 879–885.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Birkhäuser Verlag
About this chapter
Cite this chapter
Raivich, G., Kreutzberg, G.W. (1989). Topography of βNGF receptor-positive and AChe-reactive neurons in the central nervous system. In: Frotscher, M., Misgeld, U. (eds) Central Cholinergic Synaptic Transmission. Experientia Supplementum, vol 57. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9138-7_5
Download citation
DOI: https://doi.org/10.1007/978-3-0348-9138-7_5
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-0348-9922-2
Online ISBN: 978-3-0348-9138-7
eBook Packages: Springer Book Archive