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DNA Methylation and cancer

  • Chapter
DNA Methylation

Part of the book series: EXS ((EXS,volume 64))

Abstract

The methylation of cytosine at the 5′ position in the CpG dinucleotide palindrome is the only known epigenetic modification in vertebrate DNA. Although 5-methylcytosine (5-mC) comprises only 1–3% of the bases in the genome, it may play an important role in carcinogenesis through its ability to influence gene expression and increase mutational frequencies in genes involved in carcinogenesis.

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  1. Urologic Cancer Research Laboratory, Kenneth Norris Jr. Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, 90033, USA

    Charles H. Spruck III, William M. Rideout III & Peter A. Jones

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Spruck, C.H., Rideout, W.M., Jones, P.A. (1993). DNA Methylation and cancer. In: Jost, JP., Saluz, HP. (eds) DNA Methylation. EXS, vol 64. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9118-9_22

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