Abstract
It is still not clear how eukaryotic cells regulate gene expression during differentiation and in the differentiated state. There is increasing experimental evidence that this requires a wide spectrum of different cis- and trans-acting elements (for a review, see Wasylyk, 1988). One of the cis-functional elements, crucial for gene activation, is the change in the DNA methylation pattern. In mammalian cells methylation occurs exclusively at the cytosine residue in the CpG dinucleotide sequence.
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© 1993 Birkhäuser Verlag Basel/Switzerland
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Graessmann, M., Graessmann, A. (1993). DNA Methylation, chromatin structure and the regulation of gene expression. In: Jost, JP., Saluz, HP. (eds) DNA Methylation. EXS, vol 64. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9118-9_18
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DOI: https://doi.org/10.1007/978-3-0348-9118-9_18
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