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Heat shock proteins as immunological carriers and vaccines

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Book cover Stress-Inducible Cellular Responses

Part of the book series: EXS ((EXS,volume 77))

Abstract

HSPs are among the major targets of the immune response to bacterial, fungal and parasitic pathogens. The antigenic nature of HSPs is emphasized by evidence that mammals are capable of recognizing multiple B- and T cell epitopes in these proteins. The powerful immunological features of HSPs have led to their experimental use as immunomodulators and as subunit vaccine candidates. Mycobacterial hsp70 and hsp60 have been found to be excellent immunological carriers of molecules against which an immune response is desired; in the absence of adjuvants, the HSPs can stimulate strong and long-lasting immune responses against molecules which have been covalently attached to the HSPs. When used as subunit vaccines, HSPs derived from a variety of bacterial and fungal pathogens have been found to stimulate protective immunity in animal models. These studies suggest that HSPs might be used as immunomodulators or subunit vaccines against infectious disease in man.

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, 02142, USA

    K. Suzue

  2. Department of Biology Massachusetts Institute of Technology, Cambridge, MA, 02139, USA

    R. A. Young

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  1. K. Suzue
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  2. R. A. Young
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, AMGEN Center, 1840 De Havilland Drive, 15-2-A-224, 91320-1789, Thousand Oaks, CA, USA

    U. Feige

  2. Department of Cell Biology, The Tokyo Metropolitan Institute of Medical Science, Honkomagome 3-18-22, Bunkyo-Ku, Tokyo 113, Japan

    I. Yahara

  3. Department of Biochemistry, Molecular and Cell Biology Northwestern University, 2153 Sheridan Road, 60208-3500, Evanston, IL, USA

    R. I. Morimoto

  4. Laboratoire de Physiologie Respiratoire, Université Paris 5 UFR Cochin Port-Royal, 24, rue du Faubourg Saint-Jacques, F-75014, Paris, France

    B. S. Polla

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© 1996 Birkhäuser Verlag Basel/Switzerland

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Suzue, K., Young, R.A. (1996). Heat shock proteins as immunological carriers and vaccines. In: Feige, U., Yahara, I., Morimoto, R.I., Polla, B.S. (eds) Stress-Inducible Cellular Responses. EXS, vol 77. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-9088-5_30

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  • DOI: https://doi.org/10.1007/978-3-0348-9088-5_30

  • Publisher Name: Birkhäuser Basel

  • Print ISBN: 978-3-0348-9901-7

  • Online ISBN: 978-3-0348-9088-5

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